CAI0019 is an orally active α-carbonic anhydrase inhibitor based on the Acetazolamide framework. CAI0019 exhibits narrow-spectrum antibiofilm activity, with its MIC 50 being 0.094 μM and MIC 90 being 0.39 μM. CAI0019 selectively inhibits Enterococcus in a septic peritonitis mouse model, without affecting most intestinal commensal bacteria [1].
References:
[1]. Abutaleb NS, et al. Bacterial Carbonic Anhydrase Inhibitor CAI0019 Demonstrates Efficacy in Enterococcus faecium Septicemic Peritonitis Mouse Model While Sparing the Microbiome. ACS Infect Dis. 2025 Dec 11.
References:
[1]. Abutaleb NS, et al. Bacterial Carbonic Anhydrase Inhibitor CAI0019 Demonstrates Efficacy in Enterococcus faecium Septicemic Peritonitis Mouse Model While Sparing the Microbiome. ACS Infect Dis. 2025 Dec 11.