GLPBio

Cathepsin

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Cathepsins (the term standing for “lysosomal proteolytic enzyme”) are a class of globular proteases that catalyze the hydrolysis of intracellular peptides and also exhibit extracellular functions. So far, a total of sixteen members of human cathepsin family have been identified, which are divided into three subfamilies, including cysteine protease family (cathepsin B, C, F, H, L, K, O, S, V, W, X and Z), serine carboxypeptidase family (cathepsin A and G) and aspartic protease family (cathepsin D and E). Cathepsins are highly expressed in various human cancers with each member playing different roles in distinct tumorigenic processes, including proliferation, angiogenesis, metastasis and invasion.

Products Related to Cathepsin(74)

  • GA23177 structure
    GA23177Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH₂
    CAS: 839730-93-7
    Purity: >98%

    Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH₂ ist ein fluorogenes Substrat fÜr die Cathepsine D und E und nicht fÜr B, H oder L.

  • GA23711 structure
    GA23711Z-Arg-Arg-AMC
    CAS: 88937-61-5
    Purity: >98.00%

    Z-Arg-Arg-AMC is a specific substrate for histone B with an Ex/Em of 360/460nm.

  • GA23847 structure
    GA23847Z-Leu-Arg-AMC
    CAS: 156192-32-4
    Purity: >98%

    Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (AMC) leucine derivative with carboxybenzoyl (Z).

  • GA23863 structure
    GA23863Z-Leu-Val-Gly-diazomethylketone
    CAS: 119670-30-3
    Purity: >98.00%

    Z-Leu-Val-Gly-Diazomethylketon ist ein zellgÄngiger und irreversibler Inhibitor der Cysteinproteinase.

  • GA23894 structure
    GA23894Z-Phe-Arg-AMC . HCl
    CAS: 70382-26-2
    Purity: >98.50%

    Z-Phe-Arg-AMC . HCl ist ein Substrat für Serinproteasen. Dazu gehören Cathepsine, Kallikrein und Plasmin.

  • GC10027 structure
    GC10027Leupeptin, Microbial
    CAS: 103476-89-7
    Purity: >98.00%

    Leupeptin, Microbial ist ein Breitband-Serin- und Cystein-Protease-Hemmer.

  • GC10342 structure
    GC10342Calpeptin
    CAS: 117591-20-5
    Purity: >98.00%

    Calpeptin is a reversible and cell-permeable cysteine cathepsin inhibitor. The ID 50 values of Calpeptin for calpain I and II (porcine), papain, and platelet calpain I are 52nM, 34nM, 138nM, and 20nM, respectively. Calpeptin alleviates apoptosis and secondary inflammatory changes in muscle cells.

  • GC10376 structure
    GC10376Cathepsin G Inhibitor I
    CAS: 429676-93-7
    Purity: >95.00%
  • GC10377 structure
    GC10377SID 26681509
    CAS: 958772-66-2
    Purity: >98.00%
  • GC10477 structure
    GC10477PMSF
    CAS: 329-98-6
    Purity: >98.00%

    PMSF ist ein irreversibler Serinproteaseinhibitor, der oft vor der Zell- oder Gewebelyse dem Lysepuffer zugesetzt wird, um Proteinabbau zu verhindern.

  • GC11553 structure
    GC115532-cyano-Pyrimidine
    CAS: 14080-23-0
    Purity: >99.50%

    2-Cyano-Pyrimidin ist ein potenter und nicht-selektiver Cysteinprotease-Cathepsin-K-Inhibitor mit einem IC50 von 170 nM.

  • GC11640 structure
    GC11640MDL 28170
    CAS: 88191-84-8
    Purity: >97.00%

    MDL 28170, a cell permeable, reversible, peptidic aldehyde inhibitor of calpain (K i = 0.01μM; K i for cathepsin B = 0.025μM).

  • GC12751 structure
    GC12751Balicatib
    CAS: 354813-19-7
    Purity: >98.00%

    Balicatib (AAE581) ist ein potenter, oral aktiver und selektiver Cathepsin-K-Inhibitor mit IC50-Werten von 22, 61, 48, 2900 nM fÜr Cathepsin K, Cathepsin B, Cathepsin L bzw. Cathepsin S.

  • GC13418 structure
    GC13418E-64
    CAS: 66701-25-5
    Purity: >99.00%

    Ein Pilzmetabolit mit vielfältigen biologischen Aktivitäten.

  • GC13787 structure
    GC13787E 64d
    CAS: 88321-09-9
    Purity: >99.50%

    Ein Protease-Inhibitor

  • GC14903 structure
    GC14903Cathepsin S inhibitor
    CAS: 1373215-15-6
    Purity: >98.00%

    A potent cathepsin S inhibitor

  • GC15708 structure
    GC15708Cysteine Protease inhibitor hydrochloride
    CAS: 2197053-49-7
    Purity: >98%

    Cystein-Protease-Inhibitor-Hydrochlorid ist ein Inhibitor der Cystein-Protease.

  • GC15917 structure
    GC15917CA-074 Me
    CAS: 147859-80-1
    Purity: >98.00%

    CA-074 Me (CA-074 methyl ester) is a specific inhibitor of Cathepsin B(CB).

  • GC16181 structure
    GC16181Cathepsin Inhibitor 1
    CAS: 225120-65-0
    Purity: >98.00%

    Cathepsin-Inhibitor 1 (Verbindung 25) ist ein potenter und selektiver Inhibitor von Cathepsin mit pIC50-Werten von 7,9, 6,7, 6,0, 5,5 und 5,2 fÜr CatL, CatL2, CatS, CatK bzw. CatB.

  • GC16317 structure
    GC16317CA 074
    CAS: 134448-10-5
    Purity: >98.00%

    CA 074 is a selective inhibitor of cathepsin B with a K i value of 2-5 nM. CA 074 is 10000-30000 times more potent against purified rat cathepsin B than against cathepsin H and L.

  • GC16505 structure
    GC16505E-64-c
    CAS: 76684-89-4
    Purity: >99.50%

    An active metabolite of E-64d

  • GC17989 structure
    GC17989L 006235
    CAS: 294623-49-7
    Purity: >99.50%

    An inibitor of cathepsin K

  • GC19520 structure
    GC19520Cysteine Protease inhibitor
    CAS: 921625-62-9
    Purity: >95.00%

    Cystein-Protease-Inhibitor ist ein Inhibitor der Cystein-Protease.

  • GC20162 structure
    GC20162γ-poly(L-glutamic acid) macromolecule (MW 700000)
    CAS: 25513-46-6

    γ-poly(L-glutamic acid) macromolecule (MW 700000) is a high-molecular-weight biopolymer produced by microbial fermentation, characterized by water solubility and biodegradability.