Cucurbitacin D (Synonyms: (+)-Cucurbitacin D, Elatericin A, NSC 308606, NSC 521776) |
| Katalog-Nr.GC35757 |
Cucurbitacin D ist eine aktive Komponente in Cucurbita texana und unterbricht die Wechselwirkungen zwischen Hsp90 und zwei Co-Chaperonen, Cdc37 und p23. Cucurbitacin D verhindert die Reifung von Hsp90-Clients (Her2, Raf, Cdk6, pAkt) ohne Induktion der Hitzeschockreaktion. Anti-Krebs-AktivitÄt.
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Cas No.: 3877-86-9
Sample solution is provided at 25 µL, 10mM.
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Cucurbitacin D is an active component in Cucurbita texana, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity[1]. HSP90
[1]. Hall JA, et al. Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery. J Nat Prod. 2015 Apr 24;78(4):873-9.
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