DPA-714 |
Katalog-Nr.GC38384
One-Click Copy Product Info
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DPA-714 ist ein hochaffiner Translokatorprotein(TSPO)-Ligand (Ki=7 nM), der mit einem Fluoratom in seiner Struktur ausgestattet ist, was die Markierung mit Fluor-18 und die In-vivo-Bildgebung mittels Positronen-Emissions-Tomographie ermÖglicht.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 958233-07-3
Sample solution is provided at 25 µL, 10mM.
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DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7nM)[1]. DPA-714 has highly specific binding and the ability to penetrate the blood-brain barrier, which enables visualization of inflammatory processes in vivo non-invasively[2]. DPA-714 can be used as a reference substance for detecting 18F-labeled forms, thereby developing the mass spectrometry analysis method for detecting metabolite components[3].
References:
[1] James M L, Fulton R R, Vercoullie J, et al. DPA-714, a new translocator protein–specific ligand: synthesis, radiofluorination, and pharmacologic characterization[J]. Journal of Nuclear Medicine, 2008, 49(5): 814-822.
[2] Cybulska K A, Bloemers V, Perk L R, et al. Optimised GMP-compliant production of [18F] DPA-714 on the Trasis AllinOne module[J]. EJNMMI Radiopharmacy and Chemistry, 2021, 6(1): 20.
[3] Peyronneau M A, Saba W, Goutal S, et al. Metabolism and quantification of [18F] DPA-714, a new TSPO positron emission tomography radioligand[J]. Drug Metabolism and Disposition, 2013, 41(1): 122-131.
| Cas No. | 958233-07-3 | SDF | |
| Canonical SMILES | O=C(N(CC)CC)CC1=C2N=C(C)C=C(C)N2N=C1C3=CC=C(OCCF)C=C3 | ||
| Formula | C22H27FN4O2 | M.Wt | 398.47 |
| Löslichkeit | DMSO: 41.67 mg/mL (104.57 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.5096 mL | 12.548 mL | 25.096 mL |
| 5 mM | 501.9 μL | 2.5096 mL | 5.0192 mL |
| 10 mM | 251 μL | 1.2548 mL | 2.5096 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)