Glp-Amyloid-β (3-40) peptide is a fragment of amyloid-β (1-40) that contains the cyclic amino acid pyroglutamate at the N-terminus. Glp-Amyloid-β (3-40) peptide is a major component of the endogenous amyloid-β content in post-mortem brain tissue from patients with Alzheimer's disease.1 It is formed through cleavage of the N-terminal aspartate and alanine on Aβ40 and Aβ42 followed by dehydration of glutamic acid by glutaminyl cyclase.2 Glp-Amyloid-β (3-40) peptide has been used as a reference peptide for the quantification of total pyroglutamate amyloid-β in APP23 mouse brain.1
References
1. Schieb, H., Kratzin, H., Jahn, O., et al. β-Amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice. Comparison with human Alzheimer amyloid. J. Biol. Chem. 286(39), 33747-33758 (2011).
2. Jawhar, S., Wirths, O., and Bayer, T.A. Pyroglutamate amyloid-β (Aβ): A hatchet man in Alzheimer disease. J. Biol. Chem. 286(45), 38825-38832 (2011).