Glycocholic acid (Synonyms: Cholylglycine, GCA) |
| Katalog-Nr.GC34134 |
GlykocholsÄure ist eine GallensÄure mit krebsbekÄmpfender AktivitÄt, die auf mit dem Pumpwiderstand in Verbindung stehende und nicht mit dem Pumpwiderstand in Verbindung stehende Signalwege abzielt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 475-31-0
Sample solution is provided at 25 µL, 10mM.
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Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways.
Glycocholic acid (GC) increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells and the absorption of epirubicin in rat small intestine, and intensified epirubicin-induced apoptosis. Glycocholic acid and epirubicin significantly reduce mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2; downregulate the MDR1 promoter region; suppress the mRNA expression of Bcl-2; induce the mRNA expression of Bax; and significantly increase the Bax-to-Bcl-2 ratio and the mRNA levels of p53, caspase-9 and -3. A combination of anticancer drugs with Glycocholic acid can control MDR via a mechanism that involves modulating P-gp and MRPs as well as regulating apoptosis-related pathways[1].
[1]. Lo YL, et al. Inhibit multidrug resistance and induce apoptosis by using glycocholic acid and epirubicin. Eur J Pharm Sci. 2008 Sep 2;35(1-2):52-67.
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