Pramiracetam (Synonyms: ) |
Katalog-Nr.GC17374
One-Click Copy Product Info
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Pramiracetam ist ein von Piracetam abgeleitetes Nootropikum und ist stÄrker.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 68497-62-1
Sample solution is provided at 25 µL, 10mM.
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Pramiracetam is a nootropic drug [1].
Pramiracetam is investigated for its cognition-enhancing properties. A lower dosage of pramiracetam (100 mg/kg i.p.) was inadequate on NOS mRNA expression and chemical action. Interestingly, organization of pramiracetam (300 mg/kg i.p.) in rats pretreated (24 h before) with lithium chloride (LiCl) (3 mEq/kg i.p.) yielded a 40% expansion in cortical NOS action. Be that as it may, in LiCl-pretreated rats this nootropic neglected to influence cortical NOS mRNA expression; LiCl (3 mEq/kg i.p.) given alone delivered no impact. In summary, the present information show that pramiracetam given alone or in blend with LiCl builds NOS movement in mind cortical homogenates of rats and this might add to the components fundamental learning and memory change created by this nootropic. [1]
Antidementia viability of pramiracetam in 10 patients with likely Alzheimer's sickness was assessed utilizing a 2-phase, placebo-controlled, enhancement-type trial design. Eight patients prove a best dosage in the measurement finding stage, however in the ensuing replication stage just two again enhanced to a comparable degree. PETs with fluorodeoxyglucose got in two people demonstrated no distinct change. Dosages up to 4,000 mg pramiracetam are unrealistic to give symptomatic advantage to Alzheimer's infection patients. [2]
References:
[1].Systemic administration of pramiracetam increases nitric oxide synthase activity in the cerebral cortex of the rat. Funct Neurol. 1995 May-Jun;10(3):151-5.
[2].Nootropic drugs in Alzheimer's disease: symptomatic treatment with pramiracetam. Neurology. 1991 Apr;41(4):570-4.
| Cas No. | 68497-62-1 | SDF | |
| Überlieferungen | |||
| Chemical Name | N-[2-[di(propan-2-yl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide | ||
| Canonical SMILES | CC(C)N(CCNC(=O)CN1CCCC1=O)C(C)C | ||
| Formula | C14H27N3O2 | M.Wt | 269.38 |
| Löslichkeit | ≥ 10.3mg/mL in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.7122 mL | 18.5611 mL | 37.1223 mL |
| 5 mM | 742.4 μL | 3.7122 mL | 7.4245 mL |
| 10 mM | 371.2 μL | 1.8561 mL | 3.7122 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)