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MPLA

Katalog-Nr.GC18478 Copy One-Click Copy Product Info

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MPLA Chemische Struktur

Cas No.: 1246298-63-4

Größe Preis Lagerbestand Menge
500μg
300,00 $
Auf Lager
1mg
550,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.



Description of MPLA

MPLA is a synthetic derivative of lipid A, a component of bacterial LPS, that is hexa-acylated in contrast to lipid A monophosphoryl from S. minnesota R595 , which can be hepta-, hexa-, or penta-acylated. MPLA is an agonist of toll-like receptor 4 (TLR4). Intramuscular injection of MPLA (5 μg/100 μl) in mice increases injection site transcription of MyD88- and TRIF-dependent genes as well as genes encoding cytokines and cytokine receptors, chemokines, and molecules involved in the complement pathway and antigen presentation. It also increases the number of CD3+ T cells and CD11c+ GR1+ dendritic cells recruited to draining lymph nodes and increases serum levels of CCL2/MCP-1, CXCL1, CSF3, IL-6, and IL-10 by more than 10-fold compared to control animals. Emulsions containing MPLA have demonstrated efficacy as vaccine adjuvants in several mouse models, enhancing immune responses to HIV gp140 antigen and providing protection against M. tuberculosis infection.

Chemical Properties of MPLA

Cas No. 1246298-63-4 SDF
Chemical Name N/A
Canonical SMILES N/A
Formula C96H180N2O22P.NH4 M.Wt 1763.5
Löslichkeit DMSO : 25 mg/mL (14.18 mM; ultrasonic and warming and heat to 60°C) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of MPLA

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 567.1 μL 2.8353 mL 5.6705 mL
5 mM 113.4 μL 567.1 μL 1.1341 mL
10 mM 56.7 μL 283.5 μL 567.1 μL
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Berechnen

In vivo Formulation Calculator (Clear solution) of MPLA

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Bewertungen

Review for MPLA

Average Rating: 5 ★★★★★ (Based on Reviews and 9 reference(s) in Google Scholar.)

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