Pentetic acid (DTPA) is a powerful aminopolycarboxylic acid chelating agent with a structure similar to EDTA [1]. Pentetic acid binds tightly to metal ions, forming stable complexes that are rapidly excreted through urine, thereby reducing the retention and toxicity of harmful metals in the body [2]. Pentetic acid is primarily used in the treatment of radioactive contamination and as an imaging agent in medical imaging [3-4].
In PAO1 bacterial, Pentetic acid can significantly inhibit the secretion of elastase [5].
References:
[1]. Knepper T P. Synthetic chelating agents and compounds exhibiting complexing properties in the aquatic environment[J]. TrAC Trends in Analytical Chemistry, 2003, 22(10): 708-724.
[2]. Sandal N, Mahar R, Sharma P. Optimizing Ca-DTPA/Zn-DTPA therapy for internal decorporation: transitioning from intravenous to oral route with insights on safety and toxicity[J]. Journal of Radiological Protection, 2025, 45(1): 011002.
[3]. Hussain A, Alajmi M F, Ganguly S. Pentetic acid derived dual purpose fluorescent carbon dots for pH responsive drug delivery and antioxidant proficiency[J]. Diamond and Related Materials, 2024, 145: 111101.
[4]. Capra R, Marcianò N, Vignolo L A, et al. Gadolinium—Pentetic Acid Magnetic Resonance Imaging in Patients With Relapsing Remitting Multiple Sclerosis[J]. Archives of neurology, 1992, 49(7): 687-689.
[5]. Gi M, Jeong J, Lee K, et al. A drug-repositioning screening identifies pentetic acid as a potential therapeutic agent for suppressing the elastase-mediated virulence of Pseudomonas aeruginosa[J]. Antimicrobial agents and chemotherapy, 2014, 58(12): 7205-7214.