GLPBio

Apoptosis Inducers

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Apoptosis, a programmed cell death to eliminate damaged or abnormal cells, is a highly organized physiological process characterized by condensation of nuclear heterochromatin, cell shrinkage and loss of positional organization of organelles in the cytoplasm. Apoptosis inducers are a collection of compounds that are capable of inducing apoptosis in cells. Apoptosis has been extensively studied in numerous researches, where induction of apoptosis has been associated with a variety of events, including activation of p53 gene, transcription factor NF-κB or caspases. Apoptosis inducers have the potential to be incorporated into the management and therapy or prevention of cancer for their ability to induce apoptosis in cancer cells.

Products Related to Apoptosis Inducers(42)

  • GC15084 structure
    GC150842-Methoxyestradiol (2-MeOE2)
    CAS: 362-07-2
    Purity: >98.00%

    2-Methoxyestradiol (2-MeOE2)(2-MeOE2/2-Me) ist ein HIF-1α-Inhibitor.

  • GC15484 structure
    GC15484Deguelin
    CAS: 522-17-8
    Purity: >99.00%

    Deguelin is one of four major naturally occurring rotenoids isolated from root extracts and is best recognized as a NADH: ubiquinone oxidoreductase (complex I) inhibitor, resulting in significant alterations in mitochondrial function.

  • GC15878 structure
    GC15878Atractyloside Dipotassium Salt
    CAS: 102130-43-8
    Purity: >99.50%

    Inhibitor of ADP/ATP translocases

  • GC16037 structure
    GC160377BIO
    CAS: 916440-85-2
    Purity: >98%

    7BIO (7-Bromoindirubin-3-Oxime) ist das Derivat von Indirubin.

  • GC16055 structure
    GC16055SMIP004
    CAS: 143360-00-3
    Purity: >98.50%
  • GC16116 structure
    GC16116Costunolide
    CAS: 553-21-9
    Purity: >98.00%

    Costunolide is a multi-target NF-κB inhibitor with diverse biological activities.

  • GC16375 structure
    GC16375(±)-Jasmonic Acid methyl ester
    CAS: 39924-52-2
    Purity: >98.00%

    (±)-JasmonsÄuremethylester ist ein kÖrpereigener Metabolit.

  • GC16661 structure
    GC16661Citrinin
    CAS: 518-75-2
    Purity: >98.00%

    Citrinin ist ein Mycotoxin mit vielfältigen biologischen Aktivitäten, das von verschiedenen Pilzstämmen der Gattung Pencillium, Aspergillus, und Monascus gebildert wird.

  • GC16866 structure
    GC16866Actinomycin D
    CAS: 50-76-0
    Purity: >98.00%

    Actinomycin D(dactinomycin) ist ein natürliches Chromopeptid, das aus Streptomyces-Arten isoliert wird und aus einem heterozyklischen Chromophor und zwei zyklischen Pentapeptid-Lactonringen besteht.

  • GC17131 structure
    GC17131Streptozocin
    CAS: 18883-66-4
    Purity: >99.00%

    Streptozocin, ein wirksames DNA-methylierendes Antibiotikum, ist ein natürlich vorkommendes Nitrosoamid, das in experimentellen Modellen oft zur Entstehung von Diabetes verwendet wird.

  • GC17874 structure
    GC17874Matrine
    CAS: 519-02-8
    Purity: >98.00%

    Matrine is an alkaloid found in Sophora japonica plants that acts as a kappa opioid receptor and μ-receptor agonist.

  • GC17969 structure
    GC17969CHM 1
    CAS: 154554-41-3
    Purity: >98%

    An inhibitor of tubulin polymerization

  • GC18044 structure
    GC18044Trabectedin
    CAS: 114899-77-3
    Purity: >99.50%

    Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin can selectively inhibit transcription factors associated with DNA damage repair and block the DNA nucleotide excision repair pathway, leading to DNA double-strand breaks and tumor cell apoptosis. Trabectedin can also regulate the tumor microenvironment and indirectly exert antitumor effects by inhibiting the activity of tumor-associated macrophages. Trabectedin is often used in the study of soft tissue sarcoma and ovarian cancer.

  • GC19203 structure
    GC19203Lipopolysaccharides from Escherichia coli O111:B4

    Lipopolysaccharides wird aus E. coli Serotyp O111:B4 extrahiert und mittels Gel-Filtration gereinigt.

  • GN10421 structure
    GN10421Kaempferol
    CAS: 520-18-3
    Purity: >98.50%

    Ein diätetischer Flavonoid

  • GC14312 structure
    GC14312Meisoindigo
    CAS: 97207-47-1
    Purity: >98.00%

    Meisoindigo (Dian III), ein Derivat von Indirubin, stoppt den Zellzyklus in der G0/G1-Phase und induziert die Apoptose in Zellen der primÄren akuten myeloischen LeukÄmie (AML). Meisoindigo weist eine hohe AntitumoraktivitÄt auf.

  • GC15035 structure
    GC15035PM00104
    CAS: 308359-57-1
    Purity: >98%

    Potent antimyeloma agent

  • GC15036 structure
    GC15036Raltegravir potassium salt
    CAS: 871038-72-1
    Purity: >98.00%

    Raltegravir (MK 0518)-Kalium ist ein starker Integrase (IN)-Hemmer, der zur Behandlung von HIV-Infektionen eingesetzt wird.