GLPBio

E1/E2/E3 Enzyme

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Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.

Products Related to E1/E2/E3 Enzyme(113)

  • GC79627 structure
    GC79627H36-E4
    CAS: 688310-17-0
    Purity: >98.50%

    H36-E4 is a WW domain containing E3 ubiquitin 27 protein ligase 2 ( WWP2 ) inhibitor with a K D of 6.25 μM.

  • GC79628 structure
    GC79628XMU-MP-10
    CAS: 2251132-02-0
    Purity: >98.00%

    XMU-MP-10 is a selective NEDD4 inhibitor with a K D of 43.92 nM.

  • GC79629 structure
    GC79629ZER1 binder-2
    CAS: 3132618-63-1
    Purity: >98%

    ZER1 binder-2 is a ZER1 E3 ubiquitin ligase binder with an EC 50 value of 51.04 nM.

  • GC79630 structure
    GC79630MRC37
    Purity: >98.50%

    MRC37 is a high-affinity TRIM21 ligand with a K d of 0.4 µM.

  • GC79631 structure
    GC79631JWP24 acetate
    Purity: >98.00%

    JWP24 acetate is the first cell membrane-permeable peptide inhibitor of MAGE-A4, with an IC 50 of 200 nM against human MAGE-A4.

  • GC79725 structure
    GC79725DI-1548
    CAS: 2247060-97-3
    Purity: >98%

    DI-1548 is a potent, selective, and irreversible covalent inhibitor of DCN1 ( IC 50 = 4.6 nM).

  • GC79727 structure
    GC79727Tracer AL244
    Purity: >98.50%

    Tracer AL244 is a BODIPY-based fluorescent tracer and also a TRIM21 binder.

  • GC80879 structure
    GC80879JWZ-8-103 hydrochloride
    Purity: >99.50%

    JWZ-8-103 hydrochloride is an orally active analog of PRLX-93936 and a molecular glue targeting TRIM21.

  • GC80921 structure
    GC80921CCT400028
    Purity: >98.00%

    CCT400028 is a PROTACs -class degrader that targets the Aurora A (AURKA) kinase.

  • GC81022 structure
    GC81022JWZ-8-103
    CAS: 3110272-60-8
    Purity: >98.00%

    JWZ-8-103 is an orally active analog of PRLX-93936 and a molecular glue targeting TRIM21.

  • GC81024 structure
    GC81024PROTAC RNF4 degrader-1
    Purity: >98.00%

    PROTAC RNF4 degrader-1 is a RNF4 PROTAC degrader ( K d = 64.5 nM) that degrades RNF4 via the ubiquitin-proteasome system.

  • GC81026 structure
    GC81026PROTAC SKP2 Degrader-1
    CAS: 3120650-15-6
    Purity: >99.50%

    PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM.

  • GC81028 structure
    GC81028MRT-31619
    Purity: >98%

    MRT-31619 is a selective CRBN Molecular glue degrader, with an IC 50 of 14 nM and an EC 50 of 72 nM.

  • GC81029 structure
    GC81029MRT-31619 formate
    Purity: >99.00%

    MRT-31619 formate is a molecular gel degrader (MGD) targeting CRBN.

  • GC81030 structure
    GC81030XMU-MP-8
    CAS: 2271314-01-1
    Purity: >99.00%

    XMU-MP-8 (SKPer1) is a potent molecular glue degrader that targets the oncoprotein SKP2.

  • GC81515 structure
    GC81515BMS-986482
    CAS: 3062993-48-7
    Purity: >98%

    BMS-986482 is a CRBN -mediated IKZF1-4 ( Ikaros family zinc finger 1-4 ) molecular glue degrader.

  • GC81516 structure
    GC81516BMS-986482 acetate
    Purity: >98.00%

    BMS-986482 acetate is a CRBN -mediated IKZF1-4 ( Ikaros family zinc finger 1-4 ) molecular glue degrader.