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(S)-ML399

Katalog-Nr.GC80335 Copy One-Click Copy Product Info

(S)-ML399 (Compound 18S) is the enantiomer of ML399.

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(S)-ML399 Chemische Struktur

Cas No.: 1560968-51-5

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1mg
121,00 $
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5mg
302,00 $
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10mg
452,00 $
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Sample solution is provided at 25 µL, 10mM.



Description of (S)-ML399

(S)-ML399 (Compound 18S) is the enantiomer of ML399. (S)-ML399 acts as a Menin-MLL interaction inhibitor with an IC50 of 1400 nM. (S)-ML399 can be used to investigate acute leukemias with MLL translocations, including acute myeloid leukemia and acute lymphoblastic leukemia [1].

References:
[1]. He S, et al. High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction. J Med Chem. 2014;57(4):1543-1556.

Chemical Properties of (S)-ML399

Cas No. 1560968-51-5 SDF
Formula C27H28FN3O2 M.Wt 445.53
Löslichkeit Storage Store at 4°C, away from moisture
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (S)-ML399

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1 mg 5 mg 10 mg
1 mM 2.2445 mL 11.2226 mL 22.4452 mL
5 mM 448.9 μL 2.2445 mL 4.489 mL
10 mM 224.5 μL 1.1223 mL 2.2445 mL
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In vivo Formulation Calculator (Clear solution) of (S)-ML399

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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