TYA-018 is an orally active, potent and highly selective HDAC6 inhibitor. TYA-018 can protect heart function in mice. TYA-018 also enhances energetics in mice by increasing expression of targets associated with fatty acid metabolism, protein metabolism, and oxidative phosphorylation.
TYA-018 (15 mg/kg, Oral gavage, daily, for 8 weeks) protects against sarcomere damage and reduced Nppb expression in BAG3cKO mice[1].
References:
[1]. Yang J, et al. Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopat. Sci Transl Med. 2022 Jul 6;14(652):eabl5654.