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DHFR

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Dihydrofolate reductase (DHFR) is an enzyme that catalyzes the reduction of dihydrofolate (H2F) to tetrahydrofolate (H4F) utilizing nicotinamide adenine dinucleotide phosphate (NADPH) as the hydride (H-) donor, in which the pro-R hydrogen of NADPH is transferred to C6 of the pteridine ring with concomitant protonation at the N5 position. The functional DHFR gene (approximately 30 kb with six exons and five introns) has been identified to encode DHFR enzyme. Human DHFR enzyme is a monomeric protein of 186 amino acids, which is characterized by containing a highly conserved dinucleotide-binding domain consisting of seven parallel and one antiparallel β-strands intercalated by α-helices.

Products Related to DHFR(7)

  • GC10405 structure
    GC10405Methotrexate
    CAS: 59-05-2
    Purity: >98.00%

    Methotrexate is an antifolate antimetabolite that effectively inhibits the activity of dihydrofolate reductase (DHFR), with an IC 50 of approximately 7nM.

  • GC11610 structure
    GC11610Pemetrexed
    CAS: 150399-23-8
    Purity: >99.00%

    Pemetrexed (also known as pemetrexed disodium) is a novel antifolate antimetabolite targeting multiple enzymes involved in both pyrimidine and purine synthesis.

  • GC12919 structure
    GC12919Pralatrexate
    CAS: 146464-95-1
    Purity: >98.00%

    A dihydrofolate reductase inhibitor

  • GC16333 structure
    GC16333Cycloguanil (hydrochloride)
    CAS: 152-53-4
    Purity: >99.50%

    inhibitor of dihydrofolate reductase (DHFR)

  • GC17694 structure
    GC17694Pemetrexed disodium hemipenta hydrate
    CAS: 357166-30-4
    Purity: >99.00%
  • GC17867 structure
    GC17867Pyrimethamine
    CAS: 58-14-0
    Purity: >99.50%

    A dihydrofolate reductase inhibitor

  • GC73335 structure
    GC73335DHFR-IN-4
    CAS: 2820126-49-4
    Purity: >99.00%

    DHFR-IN-4 is a potent didrofolate reductase (DHFR) inhibitor with an IC50 value of 123 nM.