GLPBio

E4CPG

Catalog No.: GC13192Purity:>98.00%Synonyms: (R,S)-α-Ethyl-4-carboxyphenylglycine
group I/group II metabotropic glutamate receptor antagonist

Products are for research use only. Not for human use. We do not sell to patients.


E4CPG
Cas No.: 170846-89-6
5mgIn Stock
$54.00
1
10mgIn Stock
$72.00
1
25mgIn Stock
$162.00
1
50mgIn Stock
$288.00
1
100mgIn Stock
$432.00
1

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Description

E4CPG is a novel group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG .

References:
[1]. Sekiyama N et al. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptorsubtypes. Br J Pharmacol, 1996 Apr, 117(7):1493-503.
[2]. Bedingfield JS et al. Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs). Br J Pharmacol. 1995 Dec;116(8):3323-9.

Product Documents

Purity:>98.00%Appearance:A solid

Chemical Properties

CAS No.
170846-89-6
Synonyms
(R,S)-α-Ethyl-4-carboxyphenylglycine
Chemical Name
(S)-4-(1-amino-1-carboxypropyl)benzoic acid
SMILES
OC([C@](CC)(C1=CC=C(C(O)=O)C=C1)N)=O
Molecular Formula
C11H13NO4
Molecular Weight
223.23
Solubility
Soluble to 100 mM in 1.1eq. NaOH
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

Reviews

Review for E4CPG

Rating: 5
  • 5 Star100%
  • 4 Star0%
  • 3 Star0%
  • 2 Star0%
  • 1 Star0%