Squarunkin A hydrochloride |
| Catalog No.GC50430 |
Le chlorhydrate de Squarunkin A est un inhibiteur puissant et sélectif de l'interaction UNC119-cargo (IC50 de 10 nM pour inhiber l'interaction du peptide N-terminal Src myristoylé UNC119A). Le chlorhydrate de Squarunkin A interfère avec l'activation de la kinase Src dans les cellules.
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Cas No.: 2253744-55-5
Sample solution is provided at 25 µL, 10mM.
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Potent inhibitor of UNC119 chaperone protein-cargo interaction (IC50 = 10 nM for inhibition of UNC119A - myristoylated Src N-terminal peptide interaction). Disrupts activation of Src kinase in vitro.
Mejuch et al (2017) Small-molecule inhibition of the UNC119-cargo interaction. Angew.Chem.Int.Ed. 56 6181 PMID:28471079
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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