NKL 22 (Synonyms: Histone Deacetylase Inhibitor IV) |
| Catalog No.GC32964 |
NKL 22 (composé 4b) est un inhibiteur puissant et sélectif des histone désacétylases (HDAC), avec une IC50 de 199 et 69 nM pour HDAC1 et HDAC3, respectivement.
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Cas No.: 537034-15-4
Sample solution is provided at 25 µL, 10mM.
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NKL 22 is a HDAC inhibitor. The value of IC 50 is 78 uM NKL 22 increase frataxin protein concentrationsNKL 22 inhibitors increase FXN mRNA in FRDA lymphocytes.HDAC inhibitors act directly on FXN. [1]
[1]. D Herman et al. Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol, 2006 Oct, 2(10):551-8.
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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