Lenalidomide-OH |
Catalog No.GC60223 |
Le lénalidomide-OH est un analogue du ligand céréblon (CRBN) lénalidomide pour l'ubiquitine ligase E3, et est utilisé dans le recrutement de la protéine CRBN. Le lénalidomide-OH peut être connecté au ligand de la protéine par un lieur pour former des PROTAC, tels que le dégradeur PROTAC BTK SJF620.
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Cas No.: 1416990-08-3
Sample solution is provided at 25 µL, 10mM.
Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620 [1].
Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.
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