Cell Cycle/Checkpoint

KMG-732 is a dual-target inhibitor that targets GAK and β-tubulin, with K d values of 12.0 nM and 19.3 μM, respectively.

BJG-05-039 is an inhibitor targeting PAK1, with an IC 50 of 233 nM against human PAK1.

ATC12 is a Aurora-A kinase inhibitor.

LY3295668 (AK-01) erbumine is a highly specific and orally active inhibitor of Aurora-A kinase with a K i values for AurA and AurB of 0.8 nM and 1038 nM respectively.

CG-1521 is a histone deacetylase ( HDAC ) inhibitor that stabilizes Ac-Lys373 P53, increases P21 levels and HDAC2 degradation.

Telomeric G4s ligand 2 is an orally active, selective ligand of telomeric G-quadruplex (G4), with an IC 50 of 0.4 μM.

MS6076 is a mitochondrial protease ClpP agonist.

Berzosertib (VE-822) hydrochloride is an orally active, CNS-penetrant, and selective ATR kinase inhibitor.

AP4-43 is an orally active CLK1, CLK4, PI3K, DDR1, EGFR and NEK4 inhibitor.

CZS-241 hydrochloride is an orally active and selective inhibitor of Polo-like Kinase 4 ( PLK4 ) ( IC 50 =2.6 nM).

ROCK2-IN-12 (Compound A25) is a selective ROCK2 inhibitor with an IC 50 of 7.0 nM for ROCK2 over ROCK1.

NRL-1049 dihydrochloride (BA-1049) is a selective and orally active rho-associated protein kinase 2 ( ROCK2 ) inhibitor with an IC 50 of 0.59 μM.

8012-3246 is a selective PLK2 inhibitor with an IC 50 of 774.5 nM.

XL495 is an potent, selective and orally active PKMYT1 inhibitor.

Opitor-0 is a OPA1 GTPase inhibitor with an IC 50 of 3.0 μM.

Spire2/FMN2 PPI-IN-1 (Compound 13) dihydrochloride is a selective inhibitory fragment targeting the Spire2-FMN2 interaction, with an IC 50 of 62 μM.

Drp1 peptide inhibitor P110 (Compound P110) TFA is a selective Drp1 peptide inhibitor with neuroprotective properties.

BRD4-IN-12 is a potent and orally active BRD4 inhibitor with an IC 50 of 7.9 nM.

WX2-43 is a PRMT5-KLF4 inhibitor ( K d of 11.0 nM).

Chitosan oligosaccharide (MW 2000) is a natural oligomer derived from chitosan, with a molecular weight of 2000 Da.

Cy5-Paclitaxel bromide is a fluorescently labeled drug probe formed by conjugating the fluorescent dye Cy5 (Cyanine 5) with the chemotherapeutic agent Paclitaxel, which is used to track the cellular uptake, subcellular distribution and drug delivery process of Paclitaxel.

Carba1 is a bifunctional Carbazole derivative that activates nicotinamide phosphoribosyltransferase ( NAMPT ) and enhances NAD biosynthesis.

Gartisertib -d 8 (VX-803-d 8 ) is the deuterium labeled Gartisertib.

ARN25699 is a kinase inhibitor with an IC 50 of 5.5 nM against GSK-3β, 2.2 nM against FYN-α, and 242.3 nM against DYRK1A, and it exhibits oral bioavailability.