Innate Immunity

17(S)-HDHA is a primary mono-oxygenation product of docosahexaenoic acid in human whole blood, human leukocytes, and mouse brain.

Le cicaprost (ZK 96480) est un agoniste des récepteurs de la prostacycline (IP).

17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM).

Resolvin D2 (RvD2) is a lipid mediator biosynthesized by the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase.

Resolvin D3 methyl ester is a methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties.

(±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide.

1-Stearoyl-2-hydroxy-sn-glycero-3-PC est une forme saturée de lysophosphatidylcholine (Lyso-PC).

N-Linoleoyl phenylalanine is an endogenous N-acyl amine found in D.

Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function.

20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils.

PAF C-18:1 is a naturally occurring phospholipid produced by cells upon stimulation and plays a role in the establishment and maintenance of the inflammatory response.

Hecogenin is a natural steroid sapogenin with diverse biological activities that was originally isolated from A.

α-Phellandrene is a cyclic monoterpene that has been found in various plants, including Cannabis, and has diverse biological activities.

L'ester éthylique de l'acide linoléique inhibe le développement des lésions athérosclérotiques et l'expression des médiateurs inflammatoires.

Matairesinol confère des effets anti-allergiques dans un modèle murin de dermatite allergique.

CAY10591 est un puissant activateur de Sirt1 et supprime le TNF-α ; de manière dose-dépendante.

Sappanone A est un homoisoflavanone doté de puissantes activités antioxydantes et anti-inflammatoires.

TSI-01 est un inhibiteur sélectif de la lysophosphatidylcholine acétyltransférase 2 (LPCAT2), sa valeur d'IC50 est respectivement 0.47 et 3.02 μM pour LPCAT2 humain et LPCAT1.

(±)19(20)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 108 and 280 nM for CB1 and CB2, respectively).

Lipopolysaccharides (LPS) are components of the cell walls of Gram-negative bacteria.

(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro).

1,3-Distearoyl-2-oleoyl-rac-glycerol is a triacylglycerol that contains stearic acid at the sn-1 and sn-3 positions and oleic acid at the sn-2 position.

11(Z),14(Z)-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid, a naturally occurring PUFA.

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.