G2/M

NU 6102 is a potent CDK1 and CDK2 inhibitor with IC 50 values of 9.5nM and 5.4nM for CDK1/cyclin B and CDK2/cyclin A3, respectively.

A naturally occurring prostaglandin with antiviral/antitumor activity

Damaged DNA in humans is detected by sensor proteins that transmit a signal through checkpoint kinases (Chks) Chk1 and Chk2.

KRIBB3 is an Hsp27 and microtubule inhibitor that inhibits migration and invasion of MDA-MB-231 cells in vitro in an Hsp27-dependent manner.

Syringetin,?a flavonoid derivative, is associated with increased BMP-2 production.

BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity.

2,3-Dimethoxy-5-methyl-p-benzoquinone (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea.

Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus.

Cdc25 dual-specific protein tyrosine phosphatases are important for cell cycle progression and often overexpressed in cancers.

Globosuxanthone A is a fungal metabolite originally isolated from C.

An inhibitor of tubulin polymerization

7-oxo Staurosporine is an antibiotic originally isolated from S.

Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division.

Butyrolactone I is an ATP competitive inhibitor of cyclin-dependent kinase 1 (CDK1) with oral activity (the IC 50 value of cdc2 kinase in PC-14 cells was 20μg/ml).

Chk2 Inhibitor (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2 Inhibitor can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect.

Daphnoretin is a coumarin that has been found in W.

Darinaparsin is a novel organic arsenic compound with IC₅₀ values of 0.5–3.0µM against HL-60, Jurkat, HepG2, and A549 cells

Protopine is an alkaloid found in Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae, and Papaveraceae with diverse biological activities.

VK3-OCH3 is an analog of vitamin K3 that that has antiproliferative activities in vitro.

A bacterial metabolite with antibacterial and anticancer activities

An internal standard for the quantification of noscapine

An inhibitor of tubulin polymerization with anticancer activity

An internal standard for the quantification of griseofulvin

An internal standard for the quantification of albendazole