GLPBio

Ganoderic Acid A

Catalog No.: GN10109Purity:>98.00%
COASDSData Sheet
Ganoderic Acid A is a triterpenoid compound derived from Ganoderma lucidumand exhibits multiple biological activities.

Products are for research use only. Not for human use. We do not sell to patients.

Ganoderic Acid A
Cas No.: 81907-62-2
10mM (in 1mL DMSO)In Stock
$97.00
1
1mgIn Stock
$35.00
1
5mgIn Stock
$88.00
1
10mgIn Stock
$140.00
1
25mgIn Stock
$224.00
1
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Description

Ganoderic Acid A is a triterpenoid compound derived from Ganoderma lucidumand exhibits multiple biological activities[1-2]. Ganoderic Acid A possesses inhibitory effects against cancer, oxidation, and aging, among others[3-4].

In vitro, concurrent treatment of BV2 microglial cells with Ganoderic Acid A (50μg/ml) and LPS (0.5μg/ml) for 24 hours significantly suppressed LPS-induced proliferation and activation of BV2 microglia, and promoted the polarization of microglia from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype[5]. Treatment of MC3T3-E1 cells (induced with 1mM H₂O₂) and primary osteoblasts (induced with 250μM H₂O₂) with Ganoderic Acid A (5–80μM) for 24 hours significantly promoted osteogenic differentiation and mineralization nodule formation, and upregulated the protein expression of osteogenesis-related markers RUNX2, OPN, and β-catenin[6].

In vivo, intraperitoneal administration of Ganoderic Acid A (20–40mg/kg) 1 hour before Ovalbumin (0.1g) challenge in OVA-sensitized BALB/c mice significantly alleviated airway hyperresponsiveness and reduced the total number of inflammatory cells in bronchoalveolar lavage fluid[7]. Daily administration of Ganoderic Acid A (20mg/kg/d) via intraperitoneal injection or topical application for 6 days in Imiquimod (62.5mg per mouse)-induced psoriasiform dermatitis BALB/c mice significantly ameliorated skin erythema, thickening, and scaling, and lowered the Psoriasis Area and Severity Index (PASI) score[8].

References:
[1] Sui Q, Zhu C, Shi S, et al. Ganoderic acid A: an in-depth review of pharmacological effects and molecular docking analysis. J Ethnopharmacol. 2025 Jun 12;349:119868.
[2] Ma F, Wang J, Jiang W, et al. Ganoderic Acid A: A Potential Natural Neuroprotective Agent for Neurological Disorders: A Review. Int J Med Mushrooms. 2024;26(2):11-23.
[3] Zhang X, Huang S, Xu H, et al. Research progress on plant-derived natural compounds regulating the MAPK signaling pathway for the prevention and therapy of Alzheimer's disease. Front Pharmacol. 2025 Sep 19;16:1666082.
[4] Song Z, Wang C, Ding F, et al. Ganoderic Acid A Enhances Tumor Suppression Function of Oxaliplatin via Inducing the Cytotoxicity of T Cells. Anticancer Agents Med Chem. 2023;23(7):832-838.
[5] Jia Y, Zhang D, Yin H, et al. Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor. Neurochem Res. 2021 Jul;46(7):1725-1736.
[6] Zhao J, Fan Y, Li H, et al. Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway. Food Sci Nutr. 2025 Apr 14;13(4):e70177.
[7] Lu X, Xu C, Yang R, et al. Ganoderic Acid A Alleviates OVA-Induced Asthma in Mice. Inflammation. 2021 Oct;44(5):1908-1915.
[8] Xiao C, Chen J, Zhou X, et al. Ganoderic acid A alleviate psoriasis by inhibiting GSDMD-mediated pyroptosis. Tissue Cell. 2025 Dec;97:103078.

Protocol

Cell experiment [1]:

Cell lines

BV2 microglial cells (murine microglial cell line)

Preparation Method

BV2 cells were cultured in DMEM high glucose medium supplemented with 10% fetal bovine serum (FBS) and 1% penicillin-streptomycin at 37°C under 5% CO₂. Cells were treated with Ganoderic Acid A at 50μg/mL concurrently with LPS (0.5μg/mL) for 24 hours.

Reaction Conditions

50μg/mL; 24h

Applications

Ganoderic Acid A significantly suppressed LPS-induced BV2 microglial proliferation and activation. Ganoderic Acid A promoted the polarization of microglia from pro-inflammatory M1 to anti-inflammatory M2 phenotype.
Animal experiment [2]:

Animal models

Female BALB/c mice

Preparation Method

Mice were sensitized by intraperitoneal injection of 10mg Ovalbumin (OVA) + 1mg aluminum hydroxide in saline on days 1, 7, and 14. From day 21, they received daily OVA aerosol challenges (0.1g OVA in 10ml saline, 30min) for 7 days. Ganoderic Acid A (20 or 40mg/kg) was administered intraperitoneally 1 hour before each OVA challenge. Lung tissues and serum were collected after the final challenge for analysis.

Dosage form

20 or 40mg/kg; i.p.; Daily for 7 days.

Applications

Ganoderic Acid A significantly attenuated OVA-induced airway hyperreactivity (AHR), reduced inflammatory cell infiltration (eosinophils, lymphocytes, neutrophils) in serum and lung tissue, and decreased levels of Th2 cytokines (IL-4, IL-5, IL-13) and IgE in serum. Ganoderic Acid A also suppressed TLR4/NF-κB signaling pathway activation, as evidenced by reduced expression of TLR4, MyD88, p-NF-κB, and p-IκBα in lung tissues.

References:
[1] Jia Y, Zhang D, Yin H, et al. Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor. Neurochem Res. 2021 Jul;46(7):1725-1736.
[2] Zhao J, Fan Y, Li H, et al. Ganoderic Acid A Prevented Osteoporosis by Modulating the PIK3CA/p-Akt/TWIST1 Signaling Pathway. Food Sci Nutr. 2025 Apr 14;13(4):e70177.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
81907-62-2
Chemical Name
(2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,11-dioxo-2,5,6,7,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoic acid
SMILES
CC(CC(=O)CC(C)C(=O)O)C1CC(C2(C1(CC(=O)C3=C2C(CC4C3(CCC(=O)C4(C)C)C)O)C)C)O
Molecular Formula
C30H42O7
Molecular Weight
514.65
Solubility
DMF: 5mg/mL,DMSO: 1 mg/mL,Ethanol: 3 mg/mL
Storage
4°C, away from moisture and light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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