DL-threo-2-methylisocitrate |
| Catalog No.GC35880 |
DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 71183-66-9
Sample solution is provided at 25 µL, 10mM.
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DL-threo-2-methylisocitrate is a substrate of isocitrate lyase 1(ICL1).IC50 value:Target: The Km of purified recombinant ICL1 for threo-D(s)L(s)-isocitrate (ICA) was determined to be 188 μM using Michaelis-Menten non-linear least squares fit, with a kcat of 5.24 s-1. The Km for DL-threo-2-methylisocitrate (MICA) was approximately fourfold higher at 718 μM with a kcat of 1.25 s-1.
[1]. Gould TA, et al. Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Mol Microbiol. 2006 Aug;61(4):940-7.
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