α-Tocopherol phosphate |
Catalog No.GC37980
One-Click Copy Product Info
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α-Tocopherol phosphate is the compound demonstrating the highest vitamin E activity, which is available both in its natural form as RRR-alpha-tocopherol isolated from plant sources.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 38976-17-9
Sample solution is provided at 25 µL, 10mM.
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α-Tocopherol phosphate is a water-soluble form of α-tocopherol. α-Tocopherol phosphate functions by scavenging reactive oxygen species and regulating gene expression. α-Tocopherol phosphate can also inhibit tumor cell proliferation and induce apoptosis by modulating the activity of signaling pathways such as Hedgehog, PI3K/Akt, and Src/STAT3[1-2]. α-Tocopherol phosphate can be used in research related to antioxidation and cardiovascular diseases[3-4].
In vitro, ALDH+ MDA-MB-231 cells were co-treated with α-Tocopherol phosphate (100μM) and PS-T for 24 hours. α-Tocopherol phosphate reversed the PS-T-induced increase in lipid oxidation and malondialdehyde concentration, and prevented the inhibitory effects of PS-T on colony formation and mammosphere formation[5]. U87MG and U251 glioblastoma cells were treated with α-Tocopherol phosphate (5μM) and ferrostatin-1 for 24 hours. α-Tocopherol phosphate blocked the NKAP knockdown-induced slowdown in cell proliferation and reversed the increased cell death, apoptosis rate, and lactate dehydrogenase release caused by NKAP knockdown[6].
In vivo, SKG/Jcl mice with laminarin-induced rheumatoid arthritis were intraperitoneally administered α-Tocopherol phosphate (100mg/kg; three times a week for 7 weeks). α-Tocopherol phosphate suppressed edema in the paws and joints, improved the arthritis score, and inhibited pannus formation[7]. Male Swiss mice received a single intracerebroventricular injection of α-Tocopherol phosphate (0.1 or 1nmol/site; 3μL). Two days after the injection, α-Tocopherol phosphate reduced the expression of glutathione reductase and peroxiredoxin 2, and decreased glutathione reductase activity in the hippocampus and cerebral cortex[8].
References:
[1] Saleh MM, Lawrence KP, Jones SA, et al. The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation in keratinocytes in vitro. Sci Rep. 2021 Nov 17;11(1):22400.
[2] Wu Z, Zheng X, Meng L, et al. α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions. J Vasc Surg. 2018 Apr;67(4):1263-1273.e1.
[3] Li X, Liao XQ, Chen WR, et al. Paeonol Inhibits Cell Growth by Inducing Ferroptosis in Human Glioma Cells. Pharmacol Res Perspect. 2026 Feb;14(1):e70213.
[4] Nishio K, Ishida N, Saito Y, et al. α-Tocopheryl phosphate: uptake, hydrolysis, and antioxidant action in cultured cells and mouse. Free Radic Biol Med. 2011 Jun 15;50(12):1794-800.
[5] Zhou L, Wu Z, Luo K, et al. Polysaccharides from Huaier induce autophagy-dependent ferroptosis to inhibit breast cancer stem cells in triple-negative breast cancer. Cancer Cell Int. 2025 Dec 10;26(1):13.
[6] Sun S, Gao T, Pang B, et al. RNA binding protein NKAP protects glioblastoma cells from ferroptosis by promoting SLC7A11 mRNA splicing in an m6A-dependent manner. Cell Death Dis. 2022 Jan 21;13(1):73.
[7] Hama S, Kirimura N, Obara A, et al. Tocopheryl Phosphate Inhibits Rheumatoid Arthritis-Related Gene Expression In Vitro and Ameliorates Arthritic Symptoms in Mice. Molecules. 2022 Feb 20;27(4):1425.
[8] Uchoa MF, de Souza LF, Dos Santos, et al. Modulation of Brain Glutathione Reductase and Peroxiredoxin 2 by α-Tocopheryl Phosphate. Cell Mol Neurobiol. 2016 Aug;36(6):1015-1022.
| Cell experiment [1]: | |
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Cell lines |
ALDH+ MDA-MB-231 cells (triple-negative breast cancer stem cell-enriched population) |
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Preparation Method |
ALDH+ MDA-MB-231 cells were co-treated with α-Tocopherol phosphate (100μM) and PS-T. The ALDH+ cells were sorted and maintained in culture. |
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Reaction Conditions |
100μM; 24 hours. |
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Applications |
α-Tocopherol phosphate reversed the PS-T-induced increase in lipid oxidation and malondialdehyde concentration. α-Tocopherol phosphate also prevented the inhibitory effects of PS-T on stemness markers (POU5F1, SOX2, NANOG), as well as colony and mammosphere formation. |
| Animal experiment [2]: | |
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Animal models |
SKG/Jcl mice (laminarin-induced rheumatoid arthritis model) |
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Preparation Method |
Laminarin dissolved in PBS was intraperitoneally administered to mice to induce arthritis. Seven days after laminarin administration, α-Tocopherol phosphate (100mg/kg) dissolved in PBS was intraperitoneally administered to the mice. Control group received PBS only. |
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Dosage form |
100mg/kg; intraperitoneal injection; 3 times a week for 7 weeks. |
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Applications |
α-Tocopherol phosphate administration ameliorated the edema of the foot and joint, improved the arthritis score, and inhibited pannus formation. |
| Cas No. | 38976-17-9 | SDF | |
| Canonical SMILES | CC1=C(O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CC2)C2=C(C)C(OP(O)(O)=O)=C1C | ||
| Formula | C29H51O5P | M.Wt | 510.69 |
| Solubility | DMSO: ≥ 100 mg/mL (195.81 mM); Water: < 0.1 mg/mL (insoluble) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.9581 mL | 9.7907 mL | 19.5814 mL |
| 5 mM | 391.6 μL | 1.9581 mL | 3.9163 mL |
| 10 mM | 195.8 μL | 979.1 μL | 1.9581 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)