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GHRP-6 (acetate) (Synonyms: Growth Hormone Releasing Peptide 6, Hexapeptide-2, HWAWFK-NH2, SKF 110679, U 75799E)

Catalog No.GC45459

 

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GHRP-6 (acetate) Chemical Structure

Cas No.: 145177-42-0

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50mg
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100mg
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

GHRP-6 is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor.1,2,3,4 It inhibits binding of the GHS-R agonist MK-0677 to COS-7 cell membranes expressing human GHS-R type Ia (Ki = 1.9 nM) and binding of ghrelin to COS-7 cells expressing human GHS-R (Kd = 260 nM).2,3 GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor (EC50 = 4.5 nM) and inositol phosphate production in COS-7 cells expressing the human receptor (EC50 = 0.83 nM).3 It also acts as a negative allosteric modulator of ghrelin signaling. GHRP-6 (0.03 μg/ml) induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland.1 It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.4

References
1. Bowers, C.Y., Momany, F.A., Reynolds, G.A., et al. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 114(5), 1537-1545 (1984).
2. Howard, A.D., Feighner, S.D., Cully, D.F., et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273(5277), 974-977 (1996).
3. Holst, B., Brandt, E., Bach, A., et al. Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. Mol. Endocrinol. 19(9), 2400-2411 (2005).
4. Wren, A.M., Small, C.J., Ward, H.L., et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141(11), 4325-4328 (2000).

Chemical Properties

Cas No. 145177-42-0 SDF
Synonyms Growth Hormone Releasing Peptide 6, Hexapeptide-2, HWAWFK-NH2, SKF 110679, U 75799E
Canonical SMILES O=C(N[C@H](CC1=CC=CC=C1)C(N[C@H](C(N)=O)CCCCN)=O)[C@@H](NC([C@H](C)NC([C@H](NC([C@H](CC2=CN=CN2)N)=O)CC3=CNC4=C3C=CC=C4)=O)=O)CC5=CNC6=C5C=CC=C6.CC(O)=O.CC(O)=O.CC(O)=O
Formula C46H56N12O6.3C2H4O2 M.Wt 1053.2
Solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 0.9495 mL 4.7474 mL 9.4949 mL
5 mM 0.1899 mL 0.9495 mL 1.899 mL
10 mM 0.0949 mL 0.4747 mL 0.9495 mL
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