GLPBio

GLP-1 (7-36) acid (human, mouse, rat, porcine, bovine)

Catalog No.: GC92119Purity:>98.00%Synonyms: Glucagon-like Peptide 1 (7-36) acid
COASDSData Sheet
Glucagon-like peptide 1 (GLP-1) (7-36) acid is a derivative of the hormone and GLP-1 receptor (GLP-1R) agonist GLP-1 (7-36) amide.

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GLP-1 (7-36) acid (human, mouse, rat, porcine, bovine)
1 mgIn Stock
$35.00
1
5 mgIn Stock
$158.00
1
10 mgIn Stock
$280.00
1
25 mgIn Stock
$613.00
1
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Description

Glucagon-like peptide 1 (GLP-1) (7-36) acid is a derivative of the hormone and GLP-1 receptor (GLP-1R) agonist GLP-1 (7-36) amide.1,2 It enhances insulin-induced phosphorylation of Akt in 3T3-L1 adipocytes when used at a concentration of 100 nM in the presence of a dipeptidyl peptidase 4 (DPP-4) inhibitor.2 GLP-1 (7-36) acid (150 ?g/kg) reduces plasma levels of total cholesterol, triglycerides, free fatty acids, LDL, insulin, and leptin, as well as adipose tissue weight, in a mouse model of obesity induced by a high-fat diet. It decreases blood glucose levels, food intake, and gastric emptying in non-obese and ob/ob mice when administered at a dose of 3 mg/kg.1

References:
[1]. Fang, X., Du, Z., Duan, C., et al.Beinaglutide shows significantly beneficial effects in diabetes/obesity-induced nonalcoholic steatohepatitis in ob/ob mouse modelLife Sci.270:118966(2021).
[2]. Zhang, F., Chen, Z., Wu, D., et al.Recombinant human GLP-1 beinaglutide regulates lipid metabolism of adipose tissues in diet-induced obese miceiScience24(12)103382(2021).

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Synonyms
Glucagon-like Peptide 1 (7-36) acid
Chemical Name
L-histidyl-L-alanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-lysylglycyl-L-arginine, monoacetate
SMILES
OC(CC[C@H](NC([C@@H](NC([C@H](CC1=CN(C=N1)[H])N[H])=O)C)=O)C(NCC(N[C@@]([H])([C@@H](C)O[H])C(N[C@H](C(N[C@@]([H])([C@@H](C)O[H])C(N[C@@H](CO[H])C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CO[H])C(N[C@@H](CO[H])C(N[C@@H](CC(C=C2)=CC=C2O[H])C(N[C@H](C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CCC(N[H])=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN[H])C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@H](CC3=CN([H])C4=C3C=CC=C4)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(NCC(N[C@@H](CCC/N=C(N)\N[H])C(O)=O)=O)=O)=O)=O)CC(C)C)=O)=O)C)=O)([H])[C@H](CC)C)=O)CC5=CC=CC=C5)=O)=O)=O)C)=O)C)=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CC=CC=C6)=O)=O)=O)=O.CC(O)=O
Molecular Formula
C149H225N39O46 ? C2H4O2
Molecular Weight
3358.7
Solubility
DMSO: Sparingly soluble: 1-10 mg/ml,PBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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