GLPBio

IDO

Read More about this category

Indoleamine 2,3-dioxygenase (IDO) is an enzyme catalyzing the oxidative degradation of L-tryptophan in the kynurenine pathway, in which the pyrrole ring of L-tryptophan is cleaved to generate N-formyl-kynurenine. Mature human IDO enzyme is a 45 kDa monomeric protein of 403 amino acids that is encoded by the IDO gene (15 kb with 10 exons). According to X-ray crystallographic analysis, the chemical structure of human IDO enzyme consists of two distinct α-helical domains (one small and one large) and a heme prosthetic group, where the heme is coordinated to the active site by a histidine (His) imidazole as the proximal fifth ligand.

Products Related to IDO(46)

  • GC36294 structure
    GC36294IDO/TDO-IN-1
    CAS: 2033173-01-0
    Purity: >98%

    IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively .

  • GC36295 structure
    GC36295IDO-IN-11
    CAS: 1888378-32-2
    Purity: >98%

    IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell), extracted from patent WO 2016041489 A1, compound 13.

  • GC39127 structure
    GC39127Palmatine
    CAS: 3486-67-7
    Purity: >98%

    Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively.

  • GC61750 structure
    GC61750(Rac)-Indoximod
    CAS: 26988-72-7
    Purity: >97.00%

    (Rac)-Indoximod is an indoleamine 2,3-dioxygenase (IDO) inhibitor.

  • GC62496 structure
    GC62496BMS-986242
    CAS: 1923844-48-7
    Purity: >99.00%

    BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used for the research of cancer.

  • GC62689 structure
    GC62689PROTAC IDO1 Degrader-1
    CAS: 2488851-89-2
    Purity: >98.00%

    PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM).

  • GC64060 structure
    GC64060Kushenol E
    CAS: 99119-72-9
    Purity: >96.00%

    Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7??M and a Ki of 9.5??M, has anti-tumor activity.

  • GC64955 structure
    GC64955NLG802
    CAS: 2071683-99-1
    Purity: >99.00%

    NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.

  • GC65499 structure
    GC65499IDO1/2-IN-1 hydrochloride
    CAS: 2310286-60-1
    Purity: >98%

    IDO1/2-IN-1 hydrochloride (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 hydrochloride exhibits antitumor activies. Orally active.

  • GC65895 structure
    GC65895IDO1-IN-19
    CAS: 2328099-11-0
    Purity: >98%

    IDO1-IN-19 (Compound 17) is a potent inhibitor of IDO1. IDO1-IN-19 has the potential for the research of cancer diseases.

  • GC67714 structure
    GC67714DP00477
    CAS: 169120-56-3
    Purity: >98.00%
  • GC68133 structure
    GC68133Palmatine hydroxide
    CAS: 131-04-4
    Purity: >99.00%
  • GC69255 structure
    GC69255IDO1-IN-18
    CAS: 2328099-08-5
    Purity: >98%

    IDO1-IN-18 (Compound 14) is an effective IDO1 inhibitor. It has the potential to be used in cancer research.

  • GC69256 structure
    GC69256IDO1/TDO-IN-4
    CAS: 461424-21-5
    Purity: >98%

    IDO1/TDO-IN-4 is an effective IDO1/TDO dual inhibitor with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 can form hydrogen bonds with IDO1 and undergoes π-π stacking interactions with TDO. It can be used for research on depression, infectious diseases caused by depression, metabolic diseases, and autoimmune diseases.

  • GC69257 structure
    GC69257IDO2-IN-1
    CAS: 2803768-09-2
    Purity: >98.00%

    IDO2-IN-1 is a potent orally active inhibitor of indoleamine 2,3-dioxygenase 2 (IDO2) with an IC50 of 112 nM. It can be used for research on inflammatory autoimmune diseases.

  • GC69891 structure
    GC69891(S)-Indoximod-d3
    CAS: 1801851-87-5
    Purity: >98%

    (S)-Indoximod-d3 is the deuterated form of (S)-Indoximod. (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for cancer research.

  • GC70167 structure
    GC70167ZC0109
    Purity: >98%

    ZC0109 is a dual inhibitor of IDO1 and thioredoxin reductase 1 (TrxR1), with IC50 values of 50 nM and 3.0 μM, respectively. ZC0109 induces the accumulation of reactive oxygen species (ROS), causing cell cycle arrest at the G1/S phase and leading to apoptosis in cancer cells.

  • GC70609 structure
    GC70609(R)-IDO/TDO-IN-1
    CAS: 2033173-00-9
    Purity: >98.00%

    (R)-IDO/TDO-IN-1 (compound 25) is an indoleamine-2,3-dioxygenase (IDO) inhibitor, with good pharmacokinetic properties.

  • GC79679 structure
    GC79679Amg-1
    CAS: 496023-55-3
    Purity: >98.00%

    Amg-1 is a potent, reversible and selective indoleamine 2,3-dioxygenase ( IDO1 ) inhibitor ( IC 50 = 3.0 μM).

  • GN10414 structure
    GN10414Coptisine
    CAS: 3486-66-6
    Purity: >98%
  • GN10577 structure
    GN10577Coptisine chloride
    CAS: 6020-18-4
    Purity: >98.00%
  • GN10609 structure
    GN10609Coptisine Sulfate
    CAS: 1198398-71-8
    Purity: >98%