GLPBio

IκB/IKK

IKK (IκB kinase) is an enzyme complex that participates in NF-κB signaling pathway. It phosphorylates and inhibits IκB, thus leads to the activation of NF-κB. It is a target for treatment of inflammatory diseases and cancer.

Products Related to IκB/IKK(68)

  • GC10933 structure
    GC10933Sodium 4-Aminosalicylate
    CAS: 6018-19-5
    Purity: >99.50%

    Sodium 4-Aminosalicylate (4-Aminosalicylic acid sodium salt dihydrate) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis.

  • GC12013 structure
    GC12013Sodium salicylate
    CAS: 54-21-7
    Purity: >99.50%

    NF-κB inhibitor

  • GC12180 structure
    GC12180IKK-16 (IKK Inhibitor VII)
    CAS: 873225-46-8
    Purity: >99.00%

    IKK-16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively.

  • GC17830 structure
    GC17830IMD 0354
    CAS: 978-62-1
    Purity: >99.50%

    IKKβ inhibitor

  • GC10093 structure
    GC10093LY2409881
    CAS: 946518-60-1
    Purity: >98.50%

    LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC50 of 30 nM.

  • GC10135 structure
    GC10135AZD3264
    CAS: 1609281-86-8
    Purity: >99.50%

    IKK2 inhibitor

  • GC10592 structure
    GC10592IKK-3 Inhibitor
    CAS: 862812-98-4
    Purity: >98.50%

    A multi-kinase inhibitor

  • GC11170 structure
    GC11170Choline Fenofibrate
    CAS: 856676-23-8
    Purity: >98.00%
  • GC11508 structure
    GC11508IKK-2 inhibitor VIII
    CAS: 406209-26-5
    Purity: >99.50%
  • GC11751 structure
    GC11751QNZ (EVP4593)
    CAS: 545380-34-5
    Purity: >98.00%

    QNZ (EVP4593) is a highly potent and selective inhibitor of the nuclear factor κB (NF-κB) signaling pathway with an IC 50 value of 11nM and has anti-inflammatory effects.

  • GC12370 structure
    GC12370IKK-16 (hydrochloride)
    CAS: 1186195-62-9
    Purity: >98%

    IKK-16 (hydrochloride) is a novel, orally active selective inhibitor of IκB kinase (IKK), with IC₅₀ values of 40nM, 70nM, and 200nM against IKK-2, IKK complex, and IKK-1.

  • GC12399 structure
    GC12399BMS345541 hydrochloride
    CAS: 547757-23-3
    Purity: >99.50%

    BMS345541 hydrochloride is an orally active and highly selective inhibitor of IκB kinase (IKK). BMS345541 hydrochloride inhibits IKK-2 (IC 50 =0.3μM) and IKK-1 (IC 50 =4μM).

  • GC12609 structure
    GC12609PS 1145 dihydrochloride
    CAS: 1049743-58-9
    Purity: >98%

    IκB kinase (IKK) inhibitor

  • GC13035 structure
    GC13035Bay 11-7821
    CAS: 19542-67-7
    Purity: >95.00%

    Bay 11-7821 is an inhibitor of IκBα phosphorylation and NF-κB, selectively and irreversibly inhibits TNF-α-induced IκB-α phosphorylation (IC 50 value is approximately 10μM), and reduces the expression of NF-κB and adhesion molecules. Bay 11-7821 inhibits ubiquitin-specific proteases USP7 and USP21 with IC 50 values of 0.19 and 0.96μM, respectively .

  • GC13184 structure
    GC13184PF 184
    CAS: 1187460-81-6
    Purity: >98%

    PF 184 is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM.

  • GC13278 structure
    GC13278IKKε-IN-1
    CAS: 1292310-49-6
    Purity: >98%

    potent IKKε inhibitor

  • GC13384 structure
    GC13384WS6
    CAS: 1421227-53-3
    Purity: >98.50%

    inducer of β cell proliferation

  • GC13926 structure
    GC13926BMS-345541
    CAS: 445430-58-0
    Purity: >99.50%

    BMS-345541(free base) is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541(free base) binds at an allosteric site of IKK.

  • GC14553 structure
    GC14553Resveratrol
    CAS: 501-36-0
    Purity: >99.50%

    Resveratrol (trans-Resveratrol; SRT501) is a phytoalexin.

  • GC14989 structure
    GC14989MLN120B
    CAS: 783348-36-7
    Purity: >99.50%

    An IKKβ inhibitor

  • GC15083 structure
    GC15083Celastrol
    CAS: 34157-83-0
    Purity: >99.50%

    Celastrol is a proteasome inhibitor with a potent and preferred inhibition of purified 20S proteasome with an IC 50 of 2.5 μM.

  • GC15942 structure
    GC15942ML 120B dihydrochloride
    Purity: >98%

    IKK2-selective inhibitor

  • GC16044 structure
    GC16044Emodin
    CAS: 518-82-1
    Purity: >98.00%

    Emodin is a bioactive anthraquinone with anti-tumor, anti-bacterial, and vasorelaxant effects.

  • GC16303 structure
    GC16303Bay 65-1942 HCl salt
    CAS: 600734-06-3
    Purity: >99.00%