JNK

p-Methylphenyl potassium sulfate is a prototype protein-binding uremic toxin associated with the progression of chronic kidney disease, cardiovascular risk and mortality, derived from tyrosine and phenylalanine metabolites in the liver.

Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling.

Juglanin, a natural occurring flavonoid, is a JNK acticator, with inflammation and anti-tumor activities.

Isovitexin (Saponaretin) extracted from rice hulls of Oryza sativa , possesses various biological activities, including anti-inflammatory and antioxidant activities.

L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK.

Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo.

Thalidomide-O-PEG4-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

An inhibitor of NF-κB/AP-1

J30-8 is a potent and isoform-selective inhibitor of c-Jun N-terminal kinase 3 (JNK3) with an IC50 of 40 nM, which 2500-fold isoform selectivity against JNK1α1 and JNK2α2.

MPT0B392, an orally active quinoline derivative, induces c-Jun N-terminal kinase (JNK) activation, leading to apoptosis. MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis. MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line.

A negative control for JAK3 inhibition

DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway.

A metabolite of ellagic acid

Inflachromene is an inhibitor of HMGB1 and HMGB expression. Inflachromene can inhibit the release of HMGB1 and the NF-κB signaling pathway, exerting anti-inflammatory and neuroprotective effects. Inflachromene is mainly used to treat epilepsy.

PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase.

Tomatidine is a steroidal alkaloid that has been found in the skins and leaves of tomatoes.

A TNIK inhibitor

An active metabolite of disulfiram

High affinity JNK inhibitor; also inhibits HCMV replication

(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively.

(+)-Isomenthone is an isomer of L-Menthone, isolated from Ziziphora clinopodioidesLam. and possesses antioxidant activity.

CC-90001 is a potent, selective and orally active inhibitor of c-Jun N-terminal kinase (JNK).

(E)-Osmundacetone is the isomer of Osmundacetone.

TRi-1 is a potent, specific, and irreversible inhibitor of TXNRD1 and TXNRD2 with IC 50 values of 18nM and 44nM.