GLPBio

Aurora-A ligand 1

Catalog No.: GC82306Purity:>98.50%
COASDSData Sheet
Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (K d ) value of 0.85 nM.

製品は研究用途にのみ使用できます。人体には使用できません。患者への販売は行っておりません。

Aurora-A ligand 1
Cas No.: 2541626-73-5
10mM (in 1mL DMSO)In Stock
$128.00
1
5mgIn Stock
$117.00
1
10mgIn Stock
$186.00
1
25mgIn Stock
$372.00
1
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引用文献 (Citations)

現在、この製品の引用文献はありません。以下はGlpBio製品を引用した代表的な文献です。
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

製品説明 (Description)

Aurora-A ligand 1 is a high-affinity and specific Aurora-A inhibitor with a dissociation constant (K d ) value of 0.85 nM. Aurora-A ligand 1 can serve as a ligand for target protein ( Ligands for Target Protein for PROTAC ) for the development of PROTAC Aurora-A degraders with antitumor activity. Aurora-A ligand 1 can be used for the synthesis of HLB-0532259. HLB-0532259 shows anti-tumor activity against neuroblastoma [1].

References:
[1]. Tang J, et al. Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders. Cell Chem Biol. 2025 Jan 6:S2451-9456(24)00516-6.

製品資料 (Product Documents)

Purity:>98.50%Appearance:A solid
COASDSData Sheet

化学的性質 (Chemical Properties)

CAS番号
2541626-73-5
分子式
C21H23N5O3
分子量
393.44
溶解性
DMSO: 100 mg/mL (254.17 mM; Need ultrasonic)
保存条件
Store at -20°C
配送条件
評価用サンプルは保冷剤とともに発送します。その他の容量は室温で発送し、ご要望に応じて保冷剤を同梱します。

計算ツール (Calculators)モル濃度 / 希釈 / 分子量 / 単位変換 / in vivo製剤 / 溶解度

g/mol

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