FD 12-9 (Synonyms: Ac12Az9) |
| カタログ番号GC36034 |
FD 12-9 はフラボノイド二量体であり、P-gp と BCRP の二重阻害剤として作用し、EC50 はそれぞれ 285 nM と 0.9 nM です。抗膠芽腫活性。
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Cas No.: 1451741-22-2
Sample solution is provided at 25 µL, 10mM.
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FD 12-9 is a flavonoid dimer, acts as a dual inhibitor of P-gp and BCRP, with EC50s of 285 nM and 0.9 nM, respectively. Anti-glioblastoma activity[1]. EC50: 0.9 nM (BCRP), 285 nM (P-gp)[1]
[1]. Hu Xuesen, et al. Developing a novel strategy to treat glioblastoma : improving brain bioavailability of sorafenib with a synthetic flavonoid dimer to inhibit drug efflux in blood brain barrier.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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