SJB3-019A |
カタログ番号GC13401 |
SJB3-019A は強力な新規 USP1 阻害剤であり、SJB2-043 よりも 5 倍強力で、K562 細胞における ID1 の分解と細胞毒性を促進し、IC50 は 0.0781 μM です。
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Cas No.: 2070015-29-9
Sample solution is provided at 25 µL, 10mM.
SJB3-019A is a potent and novel inhibitor of USP1 with IC50 value of 0.0781 μM [1].
Ubiquitin-specific protease 1 (USP1) is a deubiquitinating (DUB) enzyme and removes polyubiquitin chains from the DNA binding 1 (ID1) protein, which plays an important role in the proliferation and progression of cancers, such as leukemia [1].
SJB3-019A is a potent and novel USP1 inhibitor. In K562 cells, SJB3-019A exhibited 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity. In HeLa cells, SJB3-019A increased the levels of Ub-PCNA and Ub-FANCD2 and reduced the homologous recombination activity [1].
Reference:
[1]. Mistry H, Hsieh G, Buhrlage SJ, et al. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther, 2013, 12(12): 2651-2662.
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