TMB 8 (hydrochloride) |
| カタログ番号GC19438 |
TMB 8は、TE671/RDまたはSH-SY5Y細胞で発現するヒト筋肉型およびα3β4サブユニット含有神経性アセチルコリン受容体（nAChRs）に対して、IC50値がそれぞれ390および350 nMの非競争的拮抗剤です。
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Cas No.: 53464-72-5
Sample solution is provided at 25 µL, 10mM.
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TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells. It inhibits nicotine-induced dopamine release from rat brain synaptosomes (IC50 = 480 nM). TMB 8 also reduces calcium availability in smooth and skeletal muscle, blocking the contractile response in isolated rabbit aortic strip when used at a concentration of 50 µM and inhibiting calcium influx and efflux in isolated guinea pig ileum when used at a concentration of 65 µM. It has been used in the study of intracellular calcium dynamics, particularly in smooth muscle. TMB 8 also inhibits protein kinase C (PKC) activity in a dose-dependent manner.
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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