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CDK

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<div class="colum_1 clearer"><p>CDKs (Cyclin-dependent kinases) are serine-threonine kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene. By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase.</p><p>There are around 20 Cyclin-dependent kinases (CDK1-20) known till date. CDK1, 4 and 5 are involved in cell cycle, and CDK 7, 8, 9 and 11 are associated with transcription.</p><p>CDK levels remain relatively constant throughout the cell cycle and most regulation is post-translational. Most knowledge of CDK structure and function is based on CDKs of <i>S. pombe</i> (Cdc2), <i>S. cerevisia</i> (CDC28), and vertebrates (CDC2 and CDK2). The four major mechanisms of CDK regulation are cyclin binding, CAK phosphorylation, regulatory inhibitory phosphorylation, and binding of CDK inhibitory subunits (CKIs).</p></div>

Products Related to CDK(357)

  • GC73934 structure
    GC73934Cyclin K degrader 1
    Purity: >99.00%

    Cyclin K degrader 1 (compound 40)はat7519をベースとしたサイクリンk分解器で、dc50は21 nmである。

  • GC73965 structure
    GC73965INX-315
    CAS: 2745060-92-6
    Purity: >99.00%

    INX-315は経口活性と選択的CDK 2阻害剤であり、G 1期に細胞周期ブロックを誘導することができる。

  • GC73970 structure
    GC73970CDDD11-8
    CAS: 2241659-94-7
    Purity: >99.00%

    CDDD11-8はCDK 9とFLT 3-ITDの経口活性、強力性と選択性阻害剤であり、Ki値はそれぞれ8と13 nMである。

  • GC73976 structure
    GC73976CDK2-IN-23
    CAS: 2488073-20-5
    Purity: >99.00%

    CDK2-IN-23（化合物17）はキナーゼ選択性及び高効率CDK 2阻害剤（IC 50=0.29 nM）である。

  • GC74050 structure
    GC74050PROTAC CDK4/6 degrader 1
    CAS: 3025082-14-5
    Purity: >98.00%

    PROTAC CDK4/6 degrader 1（化合物7 f）はCDK 4とCDK 6の二重分解剤であり、DC 50はそれぞれ10.5と2.5 nMである。

  • GC74161 structure
    GC74161Palbociclib hydrochloride
    CAS: 571189-11-2
    Purity: >99.50%

    Palbociclib hydrochloride (pd 0332991)は経口で選択的cdk4およびcdk6阻害剤であり、ic50はそれぞれ11 nmおよび16 nmである。

  • GC74261 structure
    GC74261(R)-(+)-O-Demethylbuchenavianine
    CAS: 1364123-68-1
    Purity: >98.00%

    (R)-(+)-O-Demethylbuchenavianineは、細胞周期タンパク質依存性キナーゼCDKの阻害剤である。

  • GC74262 structure
    GC74262(S)-(-)-O-Demethylbuchenavianine
    CAS: 91147-18-1

    (S)-(-)-O-Demethylbuchenavianine（化合物（S）−（−）−1）はフラボノイドアルカロイドである。

  • GC74324 structure
    GC74324Cdk5i peptide
    CAS: 2298317-00-5
    Purity: >99.00%

    Cdk5i peptideはcdk5由来の12アミノ酸ペプチド断片である。

  • GC74727 structure
    GC74727JSH-009
    CAS: 2247481-08-7

    JSH-009は、転写伸長の調節に重要な新規の高選択的cdk9阻害剤である。

  • GC78957 structure
    GC78957(2S,3R,4S)-ASX-173
    CAS: 2748800-07-7
    Purity: >99.00%

    (2S,3R,4S)-ASX-173 is the (2S,3R,4S)-enantiomer of ASX-173.

  • GC78958 structure
    GC78958TMLB-C16
    CAS: 2923531-50-2
    Purity: >99.00%

    TMLB-C16 is a potent and orally active B3GAT3 inhibitor with a K D of 3.962 μM.

  • GC78998 structure
    GC78998CTX-439
    CAS: 2377487-13-1
    Purity: >98.00%

    CTX-439 is an orally active, ATP-competitive small-molecule inhibitor of CDK12 and CDK13, with an IC 50 of 3.1 nM and a K d of 0.38 nM against CDK12, and an IC 50 of 9.2 nM against CDK13.

  • GC78999 structure
    GC78999CID-078
    CAS: 3064485-16-8
    Purity: >99.00%

    CID-078 is an orally active macrocyclic cyclin A and cyclin B inhibitor.

  • GC79000 structure
    GC79000Q901 TFA
    Purity: >98.50%

    Q901 (CDK7-IN-21) TFA is a selective and potent CDK7 inhibitor with an IC 50 of 10 nM.

  • GC79006 structure
    GC79006CDK2 degrader 8
    CAS: 3099145-52-2
    Purity: >98.00%

    CDK2 degrader 8 is a selective cyclin-dependent kinase 2 ( CDK2 ) degrader.

  • GC79007 structure
    GC79007Cdk2/Cyclin Inhibitory Peptide I acetate
    Purity: >99.50%

    Cdk2/Cyclin Inhibitory Peptide I (Tat-LFG) acetate, a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner [1] .

  • GC79077 structure
    GC79077DDO-6600
    CAS: 2640292-37-9
    Purity: >98.00%

    DDO-6600 is a covalent Hsp90 inhibitor.

  • GC79108 structure
    GC79108AP4-43
    Purity: >99.50%

    AP4-43 is an orally active CLK1, CLK4, PI3K, DDR1, EGFR and NEK4 inhibitor.

  • GC79121 structure
    GC79121XL495
    CAS: 3040320-93-9
    Purity: >98.00%

    XL495 is an potent, selective and orally active PKMYT1 inhibitor.

  • GC79176 structure
    GC79176ARUK2010489
    Purity: >96.50%

    ARUK2010489 (Compound 23) is a potent, selective and brain-penetrant NUAK1 inhibitor with a pIC 50 of 8.7.

  • GC80882 structure
    GC80882ZLY025
    CAS: 3070379-34-6
    Purity: >99.00%

    ZLY025 is a potent and orally active CCNK molecular glue degrader with an DC 50 of 42.7 nM.

  • GC80884 structure
    GC80884CXJ2080
    Purity: >98.00%

    CXJ2080 is a selective PROTAC-based CDK7 degrader with a DC 50 of 0.88 nM.

  • GC80885 structure
    GC80885PROTAC CDK6 Degrader 1
    Purity: >98.50%

    PROTAC CDK6 Degrader 1 (compound 48a) is a potent and selective PROTAC CDK6 degrader with a DC 50 of 0.037 μM.