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CDK

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<div class="colum_1 clearer"><p>CDKs (Cyclin-dependent kinases) are serine-threonine kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. In fact, yeast cells can proliferate normally when their CDK gene has been replaced with the homologous human gene. By definition, a CDK binds a regulatory protein called a cyclin. Without cyclin, CDK has little kinase activity; only the cyclin-CDK complex is an active kinase.</p><p>There are around 20 Cyclin-dependent kinases (CDK1-20) known till date. CDK1, 4 and 5 are involved in cell cycle, and CDK 7, 8, 9 and 11 are associated with transcription.</p><p>CDK levels remain relatively constant throughout the cell cycle and most regulation is post-translational. Most knowledge of CDK structure and function is based on CDKs of <i>S. pombe</i> (Cdc2), <i>S. cerevisia</i> (CDC28), and vertebrates (CDC2 and CDK2). The four major mechanisms of CDK regulation are cyclin binding, CAK phosphorylation, regulatory inhibitory phosphorylation, and binding of CDK inhibitory subunits (CKIs).</p></div>

Products Related to CDK(357)

  • GC80886 structure
    GC80886PROTAC CDK2/4/6 Degrader-2
    CAS: 2541626-49-5
    Purity: >97.00%

    PROTAC CDK2/4/6 Degrader-2 is a CDK2/4/6 PROTAC degrader.

  • GC80892 structure
    GC80892SR-5037
    CAS: 2387704-74-5
    Purity: >99.50%

    SR-5037 is an orally active CDK12 ( IC 50 = 31 nM)/ CDK13 inhibitor and CycK ( DC 50 = 30 nM; D max > 98%) molecular glue degrader.

  • GC80893 structure
    GC80893PROTAC CDK2/4 Degrader-1
    Purity: >98.00%

    PROTAC CDK2/4 Degrader-1 is a PROTAC degrader of cyclin-dependent kinase 2 ( CDK2 ) and cyclin-dependent kinase 4 ( CDK4 ).

  • GC80894 structure
    GC80894(S)-JWZ-5-13
    Purity: >99.50%

    (S)-JWZ-5-13 (compound 17-Neg), a PROTAC CDK7 degrader, is a negative control compound of JWZ-5-13.

  • GC80896 structure
    GC80896PROTAC D16-M1P2
    Purity: >98.00%

    PROTAC D16-M1P2 is an orally active CRBN -mediated selective PKMYT1 PROTAC degrader, with a DC 50 of 0.7 nM in CCNE1-amplified HCC1569 breast cancer cells.

  • GC81307 structure
    GC81307DYRK2-IN-2
    CAS: 2416195-65-6
    Purity: >98.00%

    DYRK2-IN-2 (Compound C17) is a selective inhibitor of DYRK2, with its IC 50 value being 40.3 nM.

  • GC81308 structure
    GC81308DYRK2-IN-2 hydrochloride
    Purity: >98.00%

    DYRK2-IN-2 hydrochloride is a selective DYRK2 inhibitor with an IC 50 of 40.3 nM.

  • GC81309 structure
    GC81309AO-365/43472821
    CAS: 1081122-55-5
    Purity: >99.50%

    AO-365/43472821 is a selective, brain-penetrant Dual-specificity tyrosine phosphorylation-regulated kinase 1A ( DYRK1A ) inhibitor ( IC 50 = 0.29 μM) and shows a significant inhibitory effect on ( CDC-like kinase 1) CLK1 ( IC 50 = 0.08 μM).

  • GC81336 structure
    GC81336KY19334
    CAS: 2319609-67-9
    Purity: >99.50%

    KY19334 is a CXXC5-DVL inhibitor.

  • GC81394 structure
    GC81394PPA-037 TFA
    Purity: >99.00%

    PPA-037 TFA is an orally active, highly potent and selective inhibitor of cyclin-dependent kinase 12 ( CDK12 ).

  • GC81453 structure
    GC81453FOXM1-IN-3
    Purity: >98.00%

    FOXM1-IN-3 is a potent FOXM1 inhibitor.

  • GC81512 structure
    GC81512dCDK9-202
    Purity: >98.50%

    dCDK9-202 is a CDK9 PROTAC degrader with a DC 50 of 3.5 nM.

  • GC81522 structure
    GC81522WWZ-11-098
    Purity: >98.00%

    WWZ-11-098 is a selective CDK6 PROTAC degrader with DC 50 of 2.6 nM.

  • GC81597 structure
    GC81597Momilactone B
    CAS: 51415-08-8
    Purity: >99.00%

    Momilactone B is an inhibitor of α-amylase and α-glucosidase, with an IC 50 of 146.85 μg/mL against Aspergillus oryzae α-amylase and an IC 50 of 612.03 μg/mL against Saccharomyces cerevisiae α-glucosidase.

  • GC81862 structure
    GC81862YJ1206 TFA
    Purity: >98.00%

    YJ1206 TFA is an orally active selective CDK12 / CDK13 PROTAC degrader.

  • GC81892 structure
    GC81892Vevorisertib tetrahydrochloride
    Purity: >98.00%

    Vevorisertib tetrahydrochloride (ARQ 751 tetrahydrochloride) is an orally active allosteric AKT inhibitor that blocks AKT phosphorylation.

  • GC91419 structure
    GC91419CYY292
    CAS: 2644673-04-9
    Purity: >98.00%

    CYY292は、PDGFRα、PDGFRβ、FGFR1、-2および-3の阻害剤であり、それぞれのIC50値は5.35、4.6、28、28および78 nMです。

  • GF04054 structure
    GF04054PROTAC CDK9 degrader-4
    CAS: 2411021-01-5
    Purity: >95.00%

    PROTAC CDK9 degrader-4 is a PROTAC protein degrader that targets CDK9 (cyclin-dependent kinase 9).

  • GN10017 structure
    GN10017Wogonin
    CAS: 632-85-9
    Purity: >98.00%

    Wogonin is a potent and competitive inhibitor of CYP1A2 with a K i value of 0.24μM.

  • GN10526 structure
    GN10526Cucurbitacin E
    CAS: 18444-66-1
    Purity: >99.50%
  • GN10696 structure
    GN10696Garcinone C
    CAS: 76996-27-5
    Purity: >98.00%