ALOX5 stabilizer-1 TFA is an arachidonate 5-lipoxygenase ( ALOX5 ) stabilizer with a K d of 7.26 μM. ALOX5 stabilizer-1 TFA inhibits β-catenin protein levels and then suppresses STAT3 signal pathway. ALOX5 stabilizer-1 TFA induces lung cancer cells apoptosis, inhibited cell migration and proliferation. ALOX5 stabilizer-1 TFA can used for the study of non-small cell lung cancer (NSCLC) [1].
In Vitro, ALOX5 stabilizer-1 (Compound 10d) (72 h) TFA inhibits NCI-H820 cell proliferation with an IC50 of 0.11 μM and shows weaker toxicity against 3T3 cells with an IC50 of 0.48 μM [1]. ALOX5 stabilizer-1 (0-0.2 μM, 10 d) TFA inhibits colony formation of with NCI-H820 cells a dose-dependent manner[1]. ALOX5 stabilizer-1 (0-0.2 μM, 48 h) TFA inhibits NCI-H820 cell migration and induces cell apoptosis[1]. ALOX5 stabilizer-1 (0-0.2 μM, 48 h) TFA directly targets ALOX5 protein and enhances protein stability, then inhibites β-catenin protein levels and eventually suppressed STAT3 signal pathway in NCI-H820 cells[1].
References:
[1]. Bai Y, et al. Design, synthesis and bioactivity evaluation of parthenolide-chalcone hybrids as potential anti-lung cancer agents. Bioorg Chem. 2025 Jul 26;164:108808.
In Vitro, ALOX5 stabilizer-1 (Compound 10d) (72 h) TFA inhibits NCI-H820 cell proliferation with an IC50 of 0.11 μM and shows weaker toxicity against 3T3 cells with an IC50 of 0.48 μM [1]. ALOX5 stabilizer-1 (0-0.2 μM, 10 d) TFA inhibits colony formation of with NCI-H820 cells a dose-dependent manner[1]. ALOX5 stabilizer-1 (0-0.2 μM, 48 h) TFA inhibits NCI-H820 cell migration and induces cell apoptosis[1]. ALOX5 stabilizer-1 (0-0.2 μM, 48 h) TFA directly targets ALOX5 protein and enhances protein stability, then inhibites β-catenin protein levels and eventually suppressed STAT3 signal pathway in NCI-H820 cells[1].
References:
[1]. Bai Y, et al. Design, synthesis and bioactivity evaluation of parthenolide-chalcone hybrids as potential anti-lung cancer agents. Bioorg Chem. 2025 Jul 26;164:108808.