CCK1-specific peptide substrate acetate is a biological active peptide. (This peptide sequence is based on rabbit muscle glycogen synthase with Ser7 phosphorylated. It is a peptide substrate for Casein Kinase I ( CK1 ). CK1 phosphorylates Ser10. Ser7 is phosphorylated by PKA in vivo.)
In Vitro, Casein kinase I is a conserved serine/threonine kinase that broadly regulates multiple core signaling pathways, serving as a key regulatory node linking cellular homeostasis to disease.
References:
[1]. Peer E, et al. Casein Kinase 1D Encodes a Novel Drug Target in Hedgehog-GLI-Driven Cancers and Tumor-Initiating Cells Resistant to SMO Inhibition. Cancers (Basel). 2021 Aug 23;13(16):4227.
In Vitro, Casein kinase I is a conserved serine/threonine kinase that broadly regulates multiple core signaling pathways, serving as a key regulatory node linking cellular homeostasis to disease.
References:
[1]. Peer E, et al. Casein Kinase 1D Encodes a Novel Drug Target in Hedgehog-GLI-Driven Cancers and Tumor-Initiating Cells Resistant to SMO Inhibition. Cancers (Basel). 2021 Aug 23;13(16):4227.