CMP-5 |
| Catalog No.GC39665 |
CMP-5는 강력하고 특이적이며 선택적인 PRMT5 억제제이지만 PRMT1, PRMT4 및 PRMT7 효소에 대해서는 활성을 나타내지 않습니다. CMP-5는 히스톤 제제에 대한 PRMT5 메틸트랜스퍼라제 활성을 억제하여 S2Me-H4R3을 선택적으로 차단합니다. CMP-5는 엡스타인-바 바이러스(EBV)에 의한 B-림프구 형질전환을 방지하지만 정상 B 세포는 영향을 받지 않습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 880813-42-3
Sample solution is provided at 25 µL, 10mM.
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CMP-5 is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Epstein-Barr virus (EBV)-driven B-lymphocyte transformation but leaving normal B cells unaffected[1][2].
[1]. Alinari L, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.Blood. 2015 Apr 16;125(16):2530-43. [2]. Webb LM, et al. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol. 2017 Feb 15;198(4):1439-1451.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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