Flavokawain B |
| Catalog No.GC41261 |
플라보카와인 B(플라보카바인 B)는 카바카바 식물의 뿌리 추출물에서 분리된 칼콘으로 다양한 암세포주의 성장을 억제하는 강력한 세포자멸사 유도제입니다. Flavokawain B(Flavokavain B)는 강력한 항혈관신생 활성을 나타냅니다. Flavokawain B(Flavokavain B)는 매우 낮고 무독성인 농도로 인간 뇌 내피 세포(HUVEC) 이동 및 관 형성을 억제합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1775-97-9
Sample solution is provided at 25 µL, 10mM.
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Flavokawain B is a natural chalcone first isolated from extracts of kava roots. It induces apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50s = 32, 48, 6.2, and 3.9 µM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours), with increased expression of the proapoptotic protein Bim. Flavokawain B increases Bim expression and inhibits growth of DU145 xenografts in mice. It also increases Bim expression, promotes apoptosis, and induces cell cycle arrest in uterine leiomyosarcoma cells. However, flavokawain B is hepatotoxic, triggering oxidative stress, inhibiting NF-κB signaling, and activating MAPK pathways, culminating in HepG2 and L-02 cell death (LD50s = 15 and 32 µM, respectively).
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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