GLPBio

MDR multidrug resistance

MDR (multidrug resistance) is a property that first identified in tumor cell, hat the resistance of tumor cell is to a variety of chemotherapy agent due to active efflux via transporter proteins.

Products Related to MDR multidrug resistance(44)

  • GC17403 structure
    GC17403Pyronaridine Tetraphosphate
    CAS: 76748-86-2
    Purity: >98.00%

    An antimalarial agent

  • GC18901 structure
    GC18901CAY10647
    CAS: 1253697-49-2
    Purity: >98%

    CAY10647 is an aryl-benzoyl-imidazole which prevents proliferation of multidrug resistant cancer cells in vitro (IC50 = 28-63 nM) and inhibits melanoma xenograph tumor growth in vivo (10-30 mg/kg).

  • GC19270 structure
    GC19270Olmutinib
    CAS: 1353550-13-6

    Olmutinib (HM61713; BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain.

  • GC40795 structure
    GC40795CAY10503
    CAS: 890854-82-7
    Purity: >98.00%

    CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase.

  • GC41564 structure
    GC41564MPT0B014
    CAS: 1215208-59-5
    Purity: >98.00%

    An inhibitor of tubulin polymerization

  • GC41629 structure
    GC41629Piperafizine A
    CAS: 130603-59-7
    Purity: >99.00%

    피페라피진 A(화합물 4d')는 N-모노알킬화 플리나불린 유도체입니다. 항암제.

  • GC41865 structure
    GC4186510'-Desmethoxystreptonigrin
    CAS: 136803-89-9
    Purity: >95.00%

    10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin.

  • GC42616 structure
    GC426167-oxo Staurosporine
    CAS: 125035-83-8
    Purity: >98.00%

    7-oxo Staurosporine is an antibiotic originally isolated from S.

  • GC42806 structure
    GC42806Andrastin A
    CAS: 174232-42-9
    Purity: >95.00%

    Andrastin A is a meroterpenoid farnesyltransferase inhibitor.

  • GC43004 structure
    GC43004C10 Ceramide (d18:1/10:0)
    CAS: 111122-57-7
    Purity: >98.00%

    C10 ceramide is an endogenous, bioactive sphingolipid produced by ceramide synthase.

  • GC43060 structure
    GC43060C2 Adamantanyl Globotriaosylceramide (d18:1/2:0)
    CAS: 261155-87-7
    Purity: >98.00%

    C2 Adamantanyl globotriaosylceramide (AdaGb3) is a bioactive sphingolipid and water-soluble form of globotriaosylceramide that contains an adamantanyl group in place of the fatty acyl chain.

  • GC44129 structure
    GC44129MC 70
    CAS: 1031367-64-2
    Purity: >98.00%

    MC 70은 EC50이 0.69μM인 강력한 비선택적 P-당단백질(P-gp) 억제제입니다. MC 70은 ABC 수송체 억제제 및 항암제입니다. MC 70은 ABCB1, ABCG2 및 ABCC1과 상호 작용합니다.

  • GC44195 structure
    GC44195Milbemycin A4 oxime
    CAS: 93074-04-5
    Purity: >98.00%

    Milbemycin A4 oxime는 milbemycin A4를 산화 및 옥심화해서 합성한 반합성 마크로라이드 화합물로 기생충 질환의 치료에 사용된다.

  • GC44613 structure
    GC44613PF-6274484
    CAS: 1035638-91-5
    Purity: >98.00%

    PF-6274484는 EGFR-L858R/T790M 및 WT EGFR에 대해 각각 0.14nM 및 0.18nM의 Kis를 갖는 강력한 EGFR 억제제입니다. PF-6274484는 각각 6.6 및 5.8 nM의 IC50으로 H1975 종양 세포에서 EGFR-L858R/T790M 자가인산화를 억제하고 A549 종양 세포에서 EGFR WT를 억제합니다.

  • GC44615 structure
    GC44615PGP-4008
    CAS: 365565-02-2
    Purity: >95.00%

    PGP-4008은 특정 P-당단백질(Pgp) 억제제입니다. PGP-4008은 독소루비신과 함께 제공될 때 쥐 동계 Pgp 매개 다중 약물 내성(MDR) 고형 종양 모델에서 종양 성장을 억제합니다.

  • GC44821 structure
    GC44821Reversin 121
    CAS: 174630-04-7
    Purity: >98.00%

    Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance.

  • GC45246 structure
    GC45246(-)-Chaetominine
    CAS: 918659-56-0
    Purity: >95.00%

    (-)-Chaetominine은 알칼로이드 대사 산물입니다. (-)-케토미닌은 인간 백혈병 K562 및 결장암 SW1116 세포주에 대해 세포독성을 갖는다. (-)-케토미닌은 K562/Adr 인간 백혈병 세포에서 PI3K/Akt/Nrf2 신호 전달 경로를 억제하여 MRP1 매개 약물 내성을 감소시킵니다.

  • GC45324 structure
    GC453242,5-dimethyl Celecoxib
    CAS: 457639-26-8
    Purity: >95.00%

  • GC45395 structure
    GC45395Cabazitaxel-d9
    CAS: 1383572-19-7
    Purity: >99.00%

    카바지탁셀-d9는 카바지탁셀로 표지된 중수소입니다. 카바지탁셀은 잠재적인 항종양 활성을 가진 천연 탁소이드 10-데아세틸바카틴 III의 반합성 유도체입니다.

  • GC45679 structure
    GC45679Carubicin
    CAS: 50935-04-1
    Purity: >98.00%

    Carubicin(Carminomycin)은 미생물 유래 화합물입니다.

  • GC45688 structure
    GC45688STX140
    CAS: 401600-86-0
    Purity: >98.00%

    An estrogen sulfamate

  • GC45784 structure
    GC45784ONT-093
    CAS: 216227-54-2
    Purity: >98.00%

    ONT-093은 P-당단백질 펌프의 강력한 억제제입니다. ONT-093은 암 연구에 대한 가능성이 있습니다.

  • GC45792 structure
    GC45792Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
    CAS: 39916-28-4
    Purity: >95.00%

    An inducer of ferroptosis

  • GC46004 structure
    GC46004Evoxanthine
    CAS: 477-82-7
    Purity: >95.00%

    An alkaloid