(-)-Chaetominine (Synonyms: (-)-Chaetominine) |
| Catalog No.GC45246 |
(-)-Chaetominine은 알칼로이드 대사 산물입니다. (-)-케토미닌은 인간 백혈병 K562 및 결장암 SW1116 세포주에 대해 세포독성을 갖는다. (-)-케토미닌은 K562/Adr 인간 백혈병 세포에서 PI3K/Akt/Nrf2 신호 전달 경로를 억제하여 MRP1 매개 약물 내성을 감소시킵니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 918659-56-0
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
(-)-Chaetominine is a cytotoxic alkaloid originally isolated from Chaetomium sp. IFB-E015. It inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM, respectively). (-)-Chaetominine induces apoptosis of K562 cells via upregulation of the Bax/Bcl-2 ratio, decreasing mitochondrial membrane potential, inducing mitochondrial cytochrome C release, and activation of caspase-3 and caspase-9. It also decreases doxorubicin efflux mediated by multidrug resistance-associated protein 1 (MRP1) and restores sensitivity to doxorubicin in resistant K562 cells.
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *