Piperafizine A |
| Catalog No.GC41629 |
피페라피진 A(화합물 4d')는 N-모노알킬화 플리나불린 유도체입니다. 항암제.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 130603-59-7
Sample solution is provided at 25 µL, 10mM.
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Piperafizine A is a natural methylated diketopiperazine first isolated from an actinomycete, Streptoverticillium. It potentiates the cytotoxicity of vincristine , an anti-cancer alkaloid known to be exported from cells by P-glycoprotein. Piperafizine A directs the intracellular accumulation of vincristine in cancer cells to a similar degree as verapamil , a P-glycoprotein inhibitor. The effects of piperafizine A on vincristine accumulation in cancer cells is dose-dependent over a range of 1 to 20 µg/ml.
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)
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