Naphthofluorescein (Synonyms: CCG 8295) |
| Catalog No.GC44313 |
Naphthofluorescein은 HIF-1과 Mint3 간의 상호 작용을 억제합니다. Naphthofluorescein은 시험관 내 세포 독성 및 생체 내 부작용 없이 암세포와 대식세포에서 Mint3 의존적 HIF-1 활성 및 해당 작용을 억제합니다. Naphthofluorescein은 또한 기능적인 Cerenkov 이미징에 사용할 수 있는 형광 pH 민감성 프로브입니다.
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Cas No.: 61419-02-1
Sample solution is provided at 25 µL, 10mM.
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Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 μM). It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP), resulting in decreased levels of active MT1-MMP. This, in turn, suppresses MMP-2 activation and reduces cell motility in CHO cells expressing proMT1-MMP. Napthofluorescein significantly inhibits the invasion of Matrigel by the human fibrosarcoma cell line, HT1080. The effects of this furin inhibitor on other furin-mediated processes, in vivo or in vitro, remain to be determined.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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