GLPBio

Drug Metabolite

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Products Related to Drug Metabolite(559)

  • GC42549 structure
    GC425495-hydroxy Thiabendazole
    CAS: 948-71-0
    Purity: >98%

    5-hydroxy Thiabendazole (5-OH TBZ) is a major metabolite of the anthelmintic thiabendazole.

  • GC42550 structure
    GC425505-hydroxy-6-methoxy (S)-Duloxetine
    CAS: 741693-79-8
    Purity: >95.00%

    5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine.

  • GC42551 structure
    GC425515-hydroxymethyl Tolterodine (formate)
    CAS: 380636-49-7
    Purity: >98.00%

    5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine and fesoterodine.

  • GC42580 structure
    GC425806-hydroxy Chlorzoxazone
    CAS: 1750-45-4
    Purity: >97.00%

    6-hydroxy Chlorzoxazone은 체내에서 클로르조사존의 주 대사 산물이다. 6-hydroxy Chlorzoxazone은 주로 간 세포색소 P450 효소계를 통해 형성되고 생화학 연구에서 CYP2E1 활성을 정량적으로 평가하기 위한 프로브로 일반적으로 사용된다.

  • GC42584 structure
    GC425846-O-desmethyl Donepezil
    CAS: 120013-56-1
    Purity: >98.00%

    6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil.

  • GC42586 structure
    GC425866α-hydroxy Paclitaxel
    CAS: 153212-75-0
    Purity: >95.00%

    6α-하이드록시 파클리탁셀은 파클리탁셀의 1차 대사산물입니다. 6α-하이드록시 파클리탁셀은 파클리탁셀과 유사한 억제 효능으로 유기 음이온 수송 폴리펩타이드 1B1/SLCO1B1(OATP1B1)에 대한 시간 의존적 효과를 유지하지만, 더 이상 OATP1B3의 시간 의존적 억제를 나타내지 않습니다. 6α-hydroxy Paclitaxel은 암 연구에 사용할 수 있습니다.

  • GC42606 structure
    GC426067-hydroxy Coumarin Glucuronide (sodium salt)
    CAS: 168286-98-4
    Purity: >95.00%

    7-hydroxy Coumarin Glucuronide (sodium salt) is a phase II metabolite of 7-hydroxycoumarin formed by glucuronidation.

  • GC42607 structure
    GC426077-hydroxy Coumarin sulfate (potassium salt)
    CAS: 1135316-80-1
    Purity: >98.00%

    7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS.

  • GC42608 structure
    GC426087-hydroxy Methotrexate (sodium salt)
    Purity: >96.00%

    7-hydroxy Methotrexate (7-hydroxy MTX) is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases.

  • GC42626 structure
    GC426268-hydroxy Efavirenz
    CAS: 205754-33-2
    Purity: >98.00%

    8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz.

  • GC42633 structure
    GC426339(E)-Erythromycin A oxime
    CAS: 111321-02-9
    Purity: >95.00%

    (9E)-Erythromycin A oxime is a metabolite of the semisynthetic antibiotic roxithromycin .

  • GC42667 structure
    GC42667Abacavir Carboxylate
    CAS: 384380-52-3
    Purity: >95.00%

    Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir.

  • GC42690 structure
    GC42690Acecainide (hydrochloride)
    CAS: 34118-92-8
    Purity: >98.00%

    Acecainide is an active metabolite of the class III antiarrhythmic procainamide.

  • GC42693 structure
    GC42693Acetaminophen Glucuronide (sodium salt)
    CAS: 120595-80-4
    Purity: >98.00%

    Acetaminophen glucuronide is an inactive metabolite of the analgesic and antipyretic agent acetaminophen.

  • GC42694 structure
    GC42694Acetaminophen sulfate (potassium salt)
    CAS: 32113-41-0
    Purity: >98.00%

    Acetaminophen sulfate is a metabolite of acetaminophen.

  • GC42769 structure
    GC42769all-trans Retinoyl β-D-Glucuronide
    CAS: 401-10-5
    Purity: >80.00%

    all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system.

  • GC42878 structure
    GC42878Avanafil metabolite M16
    CAS: 2748151-94-0
    Purity: >95.00%

    Avanafil metabolite M16 is a major inactive metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil.

  • GC42879 structure
    GC42879Avanafil metabolite M4
    Purity: >98.00%

    Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil.

  • GC42887 structure
    GC42887Axitinib Sulfoxide
    CAS: 1347304-18-0
    Purity: >98.00%

    Axitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib.

  • GC42913 structure
    GC42913Benazeprilat
    CAS: 86541-78-8
    Purity: >98.00%

    Benazeprilat은 경구 활성 및 항고혈압 활성을 갖는 카르복실 함유 ACE 억제제인 benazepril의 활성 대사산물입니다.

  • GC43140 structure
    GC43140Captopril Disulfide
    CAS: 64806-05-9
    Purity: >95.00%

    Captopril disulfide는 항고혈압 활성이 있는 Captopril의 대사 산물입니다.

  • GC43225 structure
    GC43225Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide
    CAS: 264236-79-5
    Purity: >95.00%

    Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib.

  • GC43248 structure
    GC43248Chlorzoxazone N-Glucuronide
    Purity: >95.00%

    Chlorzoxazone N-glucuronide is a phase II metabolite of the skeletal muscle relaxant chlorzoxazone.

  • GC43278 structure
    GC43278Clindamycin Sulfoxide
    CAS: 22431-46-5
    Purity: >90.00%

    Clindamycin sulfoxide is an active metabolite of the antibiotic clindamycin.