Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
Targets for Drug Metabolite
Products for Drug Metabolite
- Cat.No. 상품명 정보
- GC45208 α-hydroxy Metoprolol α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol.
- GC40480 α-Phenyl-α-(2-pyridyl)acetonitrile α-Phenyl-α-(2-pyridyl)thioacetamide, also known as antigastrin and SC-15396, is an inhibitor of gastric acid secretion.
- GC41661 (±)-4-hydroxy Propranolol β-D-Glucuronide (±)-4-hydroxy Propranolol β-D-glucuronide is a metabolite of (±)-4-hydroxy propranolol, which is a metabolite of propranolol.
- GC46284 (±)-Cotinine-d3 An internal standard for the quantification of cotinine
-
GC41671
(±)-Equol 4'-sulfate (sodium salt)
(±)-Equol 4'-sulfate is a gut-mediated phase II metabolite of the isoflavonoid phytoestrogen (±)-equol.
- GC41315 (±)-Ketoprofen Glucuronide (±)-Ketoprofen glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) ketoprofen.
- GC49875 (±)-N-desmethyl Venlafaxine (hydrochloride) A minor active metabolite of venlafaxine
- GC45252 (-)-Sitagliptin Carbamoyl Glucuronide (-)-Sitagliptin carbamoyl glucuronide is a minor phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin.
- GC18622 (2'S)-Nicotine-1-oxide (2'S)-Nicotine-1-oxide is a metabolite of nicotine .
-
GC68509
(25R)-12α-Hydroxyspirost-4-en-3-one
(25R)-12α-하이드록시스피로스트-4-엔-3-원은 노카디아 글로벌룰라가 헤코게닌에 작용하여 생성된 부생 대사산물입니다.
- GC41694 (3S)-hydroxy Quinidine (3S)-hydroxy Quinidine is an active quinidine metabolite.
- GC60399 (E)-10-Hydroxynortriptyline (E)-10-Hydroxynortriptyline(E-10-OH-NT)은 Nortriptyline의 대사 산물입니다.
- GC40286 (E,Z)-2-propyl-2-Pentenoic Acid (E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.
- GC49189 (E/Z)-4-hydroxy Tamoxifen-d5 An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
- GC62737 (R)-(-)-O-Desmethyl Venlafaxine D6
- GC41722 (R,S)-Carvedilol Glucuronide (R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide.
- GC60410 (Rac)-3′-Hydroxy simvastatin (Rac)-3′-Hydroxy simvastatin은 Simvastatin의 대사 산물입니다.
- GC40145 (S)-Laudanosine (S)-Laudanosine is the (S) enantiomer of laudanosine, a metabolite of the neuromuscular blocking agents atracurium and cisatracurium.
- GC49179 (S)-O-Desmethyl Naproxen A metabolite of (S)-naproxen
- GC60419 (S)-O-Desmethyl Venlafaxine N-Oxide (S)-O-Desmethyl Venlafaxine N-Oxide는 (S)-O-Desmethyl Venlafaxine의 N-oxyde입니다.
- GC60427 (Z)-10-Hydroxynortriptyline (Z)-10-Hydroxynortriptyline은 Nortriptyline의 대사 산물입니다.
- GC67761 (Z)-10-Hydroxynortriptyline-d3
- GC18596 (±)-2-propyl-4-Pentenoic Acid (±)-2-프로필-4-펜텐산(4-en-VPA)은 발프로산의 주요 독성 대사산물입니다.
-
GC41995
1'-hydroxy Midazolam
마취제 미다졸람의 주요 대사산물
- GC41837 1,3,7-Trimethyluric Acid 1,3,7-트리메틸요르산은 카페인의 대사산물입니다. 카페인에 대한 대사 비율 1,3,7-Trimethyluric Acid는 코호트에서 CYP3A 활성의 가변성을 설명하는 바이오마커로 평가될 수 있습니다.
- GC46387 1,3,7-Trimethyluric Acid-d9 An internal standard for the quantification of 1,3,7-trimethyluric acid
- GC49294 1-(4-Chlorobenzhydryl)piperazine An inactive metabolite of meclizine and chlorcyclizine
- GC49366 1-Salicylate Glucuronide A metabolite of salicylic acid and aspirin
- GC49820 10,11-dihydro-10,11-dihydroxy Carbamazepine A metabolite of carbamazepine and oxcarbazepine
- GC66057 10,11-Dihydrocarbamazepine 10,11-Dihydrocarbamazepine은 Oxcarbazepine의 활성 대사산물입니다. 821d96072c2d58d8970e76f526b0f6b810,11-Dihydrocarbamazepine도 중간체입니다. 821d96072c2d58d8970e76f526b0f6b8옥스카바제핀은 항경련 효과가 있는 10,11-디하이드로카르바마제핀으로 신속하고 거의 완전하게 전환됩니다.821d96072c2d58d8970e76f526b0f6b8
- GC49118 10-hydroxy Warfarin A metabolite of (R)-warfarin
- GC49759 13C17-Mycophenolic Acid An internal standard for the quantification of mycophenolic acid
- GC19442 15-Acetyldeoxy Nivalenol 15-Acetyldeoxy Nivalenol은 곡물에서 발견되는 고독성 트리코테센이며, deoxynivalenol의 대사산물로 HepG2 세포에 독성을 나타냅니다.
- GC41937 15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug.
- GC41309 16α-hydroxy Prednisolone 16α-하이드록시 프레드니솔론은 시토크롬 P450 3A(CYP3A) 효소를 통한 글루코코르티코이드 부데소나이드의 22(R) 에피머의 입체 선택적 대사 산물입니다.
- GC41300 17β-hydroxy Exemestane 17β-hydroxy Exemestane is the primary active metabolite of exemestane.
- GC49823 2′-C-β-Methylguanosine An active nucleoside metabolite of BMS-986094
- GC46508 2',2'-Difluoro-2'-deoxyuridine An active metabolite of gemcitabine
- GC49159 2-(1-Piperazinyl)pyrimidine An α2-AR antagonist and active metabolite of azapirones
- GC49330 2-(2-Aminoethyl)-3-(4-chlorophenyl)-3-hydroxyisoindol-1-one (hydrochloride) A metabolite of mazindol
- GC52029 2-Aminoflubendazole 2-아미노플루벤다졸은 벤지미다졸의 대사산물입니다.
- GC46539 2-Chloroadenine A heterocyclic building block
- GC40675 2-deoxy-Artemisinin 2-deoxy-Artemisinin is an inactive metabolite of the antimalarial agent artemisinin.
- GC35090 2-Hydroxy atorvastatin calcium salt 2-하이드록시 아토르바스타틴 칼슘염은 아토르바스타틴 칼슘염의 하이드록시 대사산물입니다.
- GC60474 2-Hydroxy atorvastatin lactone 2-Hydroxy atorvastatin lactone은 Atorvastatin의 대사 산물입니다.
- GC64336 2-Hydroxyemodin 2-Hydroxyemodin은 간 마이크로솜에서 에모딘의 활성 대사 산물입니다.
- GC42189 2-oxo Clopidogrel 2-oxo Clopidogrel is an intermediary metabolite of clopidogrel.
- GC40968 21-hydroxy Eplerenone 21-hydroxy Eplerenone is a major metabolite of the mineralocorticoid receptor antagonist eplerenone.
- GC35079 24, 25-Dihydroxy VD2 24,25-Dihydroxy VD2는 비타민 D2의 수산화 대사 산물입니다. 비타민 D의 합성 유사체.
- GC49365 25-Desacetyl Rifampicin A major active metabolite of rifampicin
- GC41480 3'-hydroxy Lidocaine 3'-hydroxy Lidocaine is an active metabolite of lidocaine formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4.
- GC39611 3'-Hydroxy Repaglinide 3'-Hydroxy Repaglinide는 Repaglinide의 주요 CYP2C8 대사 산물입니다.
- GC60500 3'-Hydroxy Repaglinide D5 3'-Hydroxy Repaglinide D5는 3'-Hydroxy Repaglinide로 표시된 중수소입니다.
- GC68082 3,4,5-Trimethoxyphenylacetic acid
- GC39841 3,4-Dehydro Cilostazol 3,4-Dehydro Cilostazol(OPC-13015)은 Cilostazol의 활성 대사 산물입니다.
- GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate A metabolite of certain phenols and glycosides
- GC42198 3-(4-Chlorophenyl)-4-hydroxybutyric Acid (sodium salt) An inactive metabolite of baclofen
- GC46583 3-Amino-2,6-Piperidinedione An active metabolite of (±)-thalidomide
- GC67902 3-Amino-2-oxazolidinone-d4
- GC42274 3-hydroxy Darifenacin 3-hydroxy Darifenacin is a metabolite of darifenacin.
- GC42275 3-hydroxy Desloratidine 3-hydroxy Desloratidine is a major metabolite of desloratadine , a tricyclic antagonist of the histamine H1 receptor.
- GC41565 3-hydroxy Medetomidine 3-hydroxy Medetomidine is a metabolite of the α2-adrenergic receptor agonist medetomidine.
- GC48457 3-keto Fusidic Acid An active metabolite of fusidic acid
- GC33738 3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride) 3-메톡시티라민 염산염(3-O-메틸 도파민 염산염)은 미량 아민 관련 수용체 1(TAAR1)을 활성화할 수 있는 도파민의 비활성 대사 산물입니다.
- GC68324 3-Methoxytyramine-d4 hydrochloride
- GC49869 3-Methoxytyrosine An active metabolite of L-DOPA
- GC42307 3-O-methyl-L-DOPA (hydrate) 3-O-methyl-L-DOPA is a metabolite of L-DOPA, produced by the activity of catechol O-methyltransferase.
- GC49367 4’-hydroxy Atomoxetine Glucuronide (hydrate) A metabolite of atomoxetine
- GC49252 4’-hydroxy Trazodone A metabolite of trazodone
- GC18527 4'-hydroxy Flurbiprofen A major active metabolite of flurbiprofen
- GC49752 4,5-Desisopropylidene Topiramate An inactive metabolite of topiramate
- GC49337 4-Acetamidobenzenesulfonamide A metabolite of asulam and sulfanilamide
- GC42370 4-desmethoxy Omeprazole 4-Desmethoxy Omeprazole은 Omeprazole의 활성 대사 산물입니다.
- GC18194 4-Epidoxycycline 4-Epidoxycycline is the 4-epimer hepatic metabolite of the antibiotic doxycycline .
-
GC42401
4-hydroperoxy Cyclophosphamide
사이클로포스파미드의 활성화된 아날로그
- GC42405 4-hydroxy Atorvastatin (calcium salt) 4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.
-
GC18425
4-hydroxy Atorvastatin lactone
4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.
- GC42407 4-hydroxy Diclofenac 4-하이드록시 디클로페낙은 시토크롬 P450 2C9(CYP2C9)에 의한 디클로페낙의 경구 활성 대사 산물입니다.
- GC49575 4-hydroxy Omeprazole sulfide A metabolite of omeprazole
- GC40879 4-hydroxy Solifenacin N-oxide 4-hydroxy Solifenacin N-oxide is an N-oxide form of 4-hydroxy solifenacin, the major metabolite of solifenacin .
- GC42415 4-hydroxy Valsartan 4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan.
-
GC18417
4-hydroxy Xylazine
4-하이드록시 실라진은 실라진의 대사산물입니다.
- GC39307 4-Methylamino antipyrine 4-Methylamino 안티피린은 Metamizole의 활성 대사 산물입니다.
- GC60523 4-Methylamino antipyrine hydrochloride 4-Methylamino antipyrine hydrochloride는 Metamizole의 활성 대사 산물입니다.
- GC49127 4-oxo Cyclophosphamide An inactive metabolite of cyclophosphamide
- GC41399 5α-dihydro Levonorgestrel 5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel.
- GC18582 5'-hydroxy Meloxicam A metabolite of meloxicam
-
GC18542
5,6-dihydro-5-Fluorouracil
5,6-dihydro-5-Fluorouracil (5-FUH2) is formed by the hydrogenation of 5-fluorouracil via the enzyme dihydropyrimidine dehydrogenase (DPD).
- GC18466 5,6-epoxy-13-cis Retinoic Acid 5,6-epoxy-13-cis Retinoic acid is a metabolite of 13-cis retinoic acid.
- GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols
- GC49655 5-hydroxy Buspirone A metabolite of buspirone
- GC42546 5-hydroxy Diclofenac 5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4.
- GC49119 5-hydroxy Flunixin A metabolite of flunixin
- GC49315 5-hydroxy Indomethacin A metabolite of indomethacin
-
GC41312
5-hydroxy Omeprazole
5-hydroxy Omeprazole is a major metabolite of omeprazole, an inhibitor of the gastric H+/K+-ATPase pump.
- GC42549 5-hydroxy Thiabendazole 5-hydroxy Thiabendazole (5-OH TBZ) is a major metabolite of the anthelmintic thiabendazole.
- GC42550 5-hydroxy-6-methoxy (S)-Duloxetine 5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine.
- GC42551 5-hydroxymethyl Tolterodine (formate) 5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine and fesoterodine.
- GC42586 6α-hydroxy Paclitaxel 6α-하이드록시 파클리탁셀은 파클리탁셀의 1차 대사산물입니다. 6α-하이드록시 파클리탁셀은 파클리탁셀과 유사한 억제 효능으로 유기 음이온 수송 폴리펩타이드 1B1/SLCO1B1(OATP1B1)에 대한 시간 의존적 효과를 유지하지만, 더 이상 OATP1B3의 시간 의존적 억제를 나타내지 않습니다. 6α-hydroxy Paclitaxel은 암 연구에 사용할 수 있습니다.
- GC49676 6β-hydroxy Budesonide A metabolite of budesonide