6α-hydroxy Paclitaxel (Synonyms: 6α-hydroxy Taxol) |
Catalog No.GC42586
One-Click Copy Product Info
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6α-하이드록시 파클리탁셀은 파클리탁셀의 1차 대사산물입니다. 6α-하이드록시 파클리탁셀은 파클리탁셀과 유사한 억제 효능으로 유기 음이온 수송 폴리펩타이드 1B1/SLCO1B1(OATP1B1)에 대한 시간 의존적 효과를 유지하지만, 더 이상 OATP1B3의 시간 의존적 억제를 나타내지 않습니다. 6α-hydroxy Paclitaxel은 암 연구에 사용할 수 있습니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 153212-75-0
Sample solution is provided at 25 µL, 10mM.
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6α-hydroxy Paclitaxel is a primary metabolite of the anticancer compound paclitaxel , produced by the action of the cytochrome P450 isoform CYP2C8. The generation of 6α-hydroxy paclitaxel by CYP2C8 can be impacted by other drugs or dietary components that interefere with CYP2C8 activity, as well as by CYP2C8 genetic polymorphisms.
| Cas No. | 153212-75-0 | SDF | |
| Synonyms | 6α-hydroxy Taxol | ||
| Canonical SMILES | O[C@@H](C(O[C@H]1C[C@]([C@H]2OC(C3=CC=CC=C3)=O)(O)C(C)(C)C([C@@H](OC(C)=O)C([C@@]4(C)[C@@]2([H])[C@](OC(C)=O)(CO5)[C@H]5[C@@H](O)[C@@H]4O)=O)=C1C)=O)[C@@H](NC(C6=CC=CC=C6)=O)C7=CC=CC=C7 | ||
| Formula | C47H51NO15 | M.Wt | 869.9 |
| Solubility | DMSO: 30 mg/ml,Methanol: 10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.1496 mL | 5.7478 mL | 11.4956 mL |
| 5 mM | 229.9 μL | 1.1496 mL | 2.2991 mL |
| 10 mM | 115 μL | 574.8 μL | 1.1496 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)