Lipoxygenase
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Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Products Related to Lipoxygenase(264)
- GC48041Resolvin D1-d5CAS: 1881277-32-2Purity: >99.00%
An internal standard for the quantification of RvD1
- GC48042Resolvin D2-d5CAS: 1881277-33-3Purity: >95.00%
An internal standard for the quantification of RvD2
- GC48043Resolvin D3-d5CAS: 916888-47-6Purity: >99.00%
A neuropeptide with diverse biological activities
- GC48267Zileuton-d4CAS: 1189878-76-9Purity: >99.00%
An internal standard for the quantification of zileuton
- GC48659UmbellipreninCAS: 532-16-1; 23838-17-7Purity: >98.00%
A prenylated coumarin with diverse biological activities
- GC48850Carbazomycin CCAS: 108073-62-7Purity: >95.00%
A bacterial metabolite with diverse biological activities
- GC48893Carbazomycin BCAS: 75139-38-7Purity: >95.00%
A bacterial metabolite with diverse biological activities
- GC49590Docosahexaenoic Acid 1,2,3,4-13CPurity: >95.00%
An internal standard for the quantification of DHA
- GC497301-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11Purity: >99.00%
An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE- sn -glycero-3-PE
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC48041 | Resolvin D1-d5 | 1881277-32-2 | >99.00% | |
An internal standard for the quantification of RvD1 | ||||
| GC48042 | Resolvin D2-d5 | 1881277-33-3 | >95.00% | |
An internal standard for the quantification of RvD2 | ||||
| GC48043 | Resolvin D3-d5 | 916888-47-6 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC48044 | Resolvin E1-d4 | - | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC48045 | Resolvin E4 | 1781227-87-9 | >95.00% | |
A specialized pro-resolving mediator | ||||
| GC48267 | Zileuton-d4 | 1189878-76-9 | >99.00% | |
An internal standard for the quantification of zileuton | ||||
| GC48659 | Umbelliprenin | 532-16-1; 23838-17-7 | >98.00% | |
A prenylated coumarin with diverse biological activities | ||||
| GC48738 | (±)12-HETE-d8 | 2525175-25-9 | >99.00% | |
| GC48739 | (±)15-HETE-d8 | 2525175-31-7 | >99.00% | |
| GC48850 | Carbazomycin C | 108073-62-7 | >95.00% | |
A bacterial metabolite with diverse biological activities | ||||
| GC48893 | Carbazomycin B | 75139-38-7 | >95.00% | |
A bacterial metabolite with diverse biological activities | ||||
| GC48972 | Resolvin E2 | 865532-70-3 | >95.00% | |
A specialized pro-resolving mediator | ||||
| GC48993 | Protectin D1-d5 | - | >99.00% | |
An internal standard for the quantification of protectin D1 | ||||
| GC49098 | Olsalazine-13C6 | - | >98.00% | |
An internal standard for the quantification of olsalazine | ||||
| GC49356 | 17(S)-HDoTE | 105835-39-0 | >98.00% | |
A metabolite of adrenic acid | ||||
| GC49364 | 3-Hydroxycoumarin | 939-19-5 | >97.00% | |
3-하이드록시쿠마린은 인간 15-LOX-1의 강력한 산화환원 억제제입니다. | ||||
| GC49386 | Tepoxalin | 103475-41-8 | >98.00% | |
테폭살린은 COX와 5-LO(5-lipoxygenase)의 이중 억제제로서 강력한 항염증 활성과 유리한 위장 프로필을 가지고 있습니다. | ||||
| GC49590 | Docosahexaenoic Acid 1,2,3,4-13C | - | >95.00% | |
An internal standard for the quantification of DHA | ||||
| GC49597 | Leukotriene B4-d5 | - | >99.00% | |
An internal standard for the quantification of LTB 4 | ||||
| GC49696 | FPL 55712 (sodium salt) | 40786-08-1 | >98.00% | |
A leukotriene receptor antagonist | ||||
| GC49730 | 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11 | - | >99.00% | |
An internal standard for the quantification of 1-stearoyl-2-15(S)-HETE- sn -glycero-3-PE | ||||
| GC49758 | CAY10788 | 119515-00-3 | >95.00% | |
A CysLT 1 receptor antagonist | ||||
| GC49778 | Etheroleic Acid | 169217-38-3 | >98.00% | |
A divinyl ether oxylipin | ||||
| GC49849 | 3-Aminosalicylic Acid | 570-23-0 | >98.00% | |
A salicylic acid derivative | ||||