>>Analytical Standards>>Resolvin D1-d5

Resolvin D1-d5 (Synonyms: 17(S)Resolvin D1d5, RvD1d5)

Catalog No.GC48041 Copy One-Click Copy Product Info

An internal standard for the quantification of RvD1

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Resolvin D1-d5 Chemical Structure

Cas No.: 1881277-32-2

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10ug
US$313.00
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25ug
US$704.00
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Sample solution is provided at 25 µL, 10mM.



Description of Resolvin D1-d5

Resolvin D1-d5 (RvD1-d5) is intended for use as an internal standard for the quantification of RvD1 by GC- or LC-mass spectrometry. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid .1 In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.2 RvD1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.1 A 17(R)-epimer of RvD1 can also be generated in aspirin-treated samples.3 Both RvD1 and its 17(R) configuration reduce human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM.4 RvD1 and its aspirin-triggered form also exhibit a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.4

1.Hong, S., Gronert, K., Devchand, P.R., et al.Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammationJ. Biol. Chem.278(17)14677-14687(2003) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Serhan, C.N., Hong, S., Gronert, K., et al.Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signalsJ. Exp. Med.196(8)1025-1037(2002) 4.Sun, Y.P., Oh, S.F., Uddin, J., et al.Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivationThe Journal of Biological Chemisty282(13)9323-9334(2007)

Chemical Properties of Resolvin D1-d5

Cas No. 1881277-32-2 SDF
Synonyms 17(S)Resolvin D1d5, RvD1d5
Canonical SMILES O[C@@H](C/C=C\C([2H])([2H])C([2H])([2H])[2H])/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O
Formula C22H27D5O5 M.Wt 381.5
Solubility DMF: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): .05 mg/ml Storage Store at -80°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Resolvin D1-d5

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1 mg 5 mg 10 mg
1 mM 2.6212 mL 13.1062 mL 26.2123 mL
5 mM 524.2 μL 2.6212 mL 5.2425 mL
10 mM 262.1 μL 1.3106 mL 2.6212 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 16 reference(s) in Google Scholar.)

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