>>Lipids>> Fatty Acids>>Resolvin D2-d5

Resolvin D2-d5 (Synonyms: 7(S),16(R),17(S)Resolvin D2d5, RvD2d5)

Catalog No.GC48042 Copy One-Click Copy Product Info

An internal standard for the quantification of RvD2

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Resolvin D2-d5 Chemical Structure

Cas No.: 1881277-33-3

Size 가격 재고 수량
10 μg
US$313.00
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25 μg
US$704.00
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Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.



Description of Resolvin D2-d5

Resolvin D2-d5 (RvD2-d5) is intended for use as an internal standard for the quantification of resolvin D2 by GC- or LC-MS. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).1 In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.2 Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation.3 It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM.3 Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.3

1.Hong, S., Gronert, K., Devchand, P.R., et al.Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammationJ. Biol. Chem.278(17)14677-14687(2003) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Spite, M., Norling, L.V., Summers, L., et al.Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsisNature461(7268)1287-1291(2009)

Chemical Properties of Resolvin D2-d5

Cas No. 1881277-33-3 SDF
Synonyms 7(S),16(R),17(S)Resolvin D2d5, RvD2d5
Canonical SMILES [2H]C([2H])(C([2H])([2H])[2H])/C=C\C[C@H](O)[C@H](O)/C=C/C=C/C=C\C=C\[C@@H](O)C/C=C\CCC(O)=O
Formula C22H27D5O5 M.Wt 381.5
Solubility Storage Store at -80°C,protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Resolvin D2-d5

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1 mg 5 mg 10 mg
1 mM 2.6212 mL 13.1062 mL 26.2123 mL
5 mM 524.2 μL 2.6212 mL 5.2425 mL
10 mM 262.1 μL 1.3106 mL 2.6212 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for Resolvin D2-d5

Average Rating: 5 ★★★★★ (Based on Reviews and 17 reference(s) in Google Scholar.)

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