Phenidone |
| Catalog No.GC61180 |
cyclooxygenase(COX)와 lipoxygenase(LOX)의 경구 활성 이중 억제제인 Phenidone은 실험적인 자가면역 뇌척수염에서 쥐의 마비를 개선합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 92-43-3
Sample solution is provided at 25 µL, 10mM.
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Phenidone, an orally active dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), ameliorates rat paralysis in experimental autoimmune encephalomyelitis. Phenidone is a potent hypotensive agent in the spontaneously hypertensive rat[1][2]. Phenidone is used as a photographic developer[3].
Phenidone significantly inhibits the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE)[1].
Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat[2].
[1]. Moon C, et al. Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. Brain Res. 2005;1035(2):206-210. [2]. Stern N, et al. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat. Am J Hypertens. 1993;6(1):52-58. [3]. Petrakiev A, et al. Emission spectral analysis using photographic plates treated with a phenidone developer. Talanta. 1969;16(12):1583-1587.
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GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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